Last reviewed · How we verify
NCT06247306: NeuStress
Using Neurofeedback to Understand the Relationship Between Stress and Alcohol Consumption
NA trial testing ScanSTRESS fMRI-paradigm (Streit et al., 2014) in Alcohol Abuse in 102 participants. Currently enrolling.
1 December 2026
Quick facts
| Lead sponsor | Central Institute of Mental Health, Mannheim |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | basic science |
| Enrollment | 102 |
| Start date | 1 March 2024 |
| Primary completion | 1 December 2026 |
| Estimated completion | 1 July 2027 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- ScanSTRESS fMRI-paradigm (Streit et al., 2014)
- real-time fMRI neurofeedback
Conditions studied
- Alcohol Abuse — all drugs for Alcohol Abuse →
- Craving — all drugs for Craving →
- Psychosocial Stressor — all drugs for Psychosocial Stressor →
- Neural Stress Response — all drugs for Neural Stress Response →
Sponsor
Central Institute of Mental Health, Mannheim
Who can join
Adults 18 to 65, any sex, with Alcohol Abuse or Craving. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In this research project, the aim is to discover the role specific brain networks play in the relationship between stress reactions and the desire for alcohol and alcohol consumption. To investigate this question, various brain imaging methods as well as cognitive tasks are combined. Various questionnaires are sampled and brain scans are conducted. Individuals interested in participating in the study have to fulfill certain criteria... * no serious medical or mental health diagnosis * problematic alcohol drinking habits * interested in improving drinking habits ...and undergo various non-invasive procedures * filling out several questionnaires concerning personality and habits * undergoing a mental performance task while being in a brain scanner (MRI) * attempting to regulate their own brain activity while lying in the MRI scanner * filling out an electronic diary for 6 weeks - concerning daily mood, stress, and alcohol habits Participants will be randomly allocated to either one of 2 experimental groups. Both groups undergo the same tasks, receive the same instructions and only differ regarding some aspects of the brain self-regulation task .
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06247306
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Central Institute of Mental Health, Mannheim trials
Trials by the same sponsor.
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- NCT06959342 — Modification of Inhibitory Control and Craving Through Transcranial Direct Current Stimulation (tDCS) as an Add-On Treat · NA · recruiting
- NCT06881810 — Enhancing Social Skills in Schizophrenia Spectrum Disorders - Oxytocin as add-on to Psychosocial Treatment · Phase 2 · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06247306 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Central Institute of Mental Health, Mannheim
- Last refreshed: 23 January 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06247306.
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