Last reviewed · How we verify
NCT06243016: HIIT2SITLess
Breaking Sitting with High-intensity Interval Training for Brain Health
NA trial testing High-Intensity Interval Training (HIIT) Breaks to Sitting in Aging in 54 participants. Currently enrolling.
31 July 2025
Quick facts
| Lead sponsor | University of Illinois at Urbana-Champaign |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 54 |
| Start date | 7 May 2024 |
| Primary completion | 31 July 2025 |
| Estimated completion | 31 July 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- High-Intensity Interval Training (HIIT) Breaks to Sitting
- Light-Intensity Interval Training (LIIT) Breaks to Sitting
Conditions studied
- Aging — all drugs for Aging →
Sponsor
University of Illinois at Urbana-Champaign
Who can join
Adults 40 to 75, any sex, with Aging. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This trial will examine whether interrupting 3.5 hours of sitting every 30 min with 6 min high intensity interval training (HIIT) breaks compared to light intensity interval training (LIIT) will improve brain health in cognitively normal older adults. This trial will test the feasibility of HIIT breaks to sitting. It will also address several important but unanswered questions: (1) Does interrupting sitting with short HIIT breaks improve frontoparietal function? (2) Can interrupting sitting with HIIT breaks improve cognitive functions?
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Breaking prolonged sitting with high-intensity interval training to improve cognitive and brain health in middle-aged and older adults: a protocol for the pilot feasibility HIIT2SITLess trial.
Pindus DM, Paluska S, So J, Wyczesany M, et al · · 2025 · PMID 40341152 · DOI 10.1136/bmjopen-2024-095415
Verify or expand the search:
- PubMed search for NCT06243016
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06243016 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Illinois at Urbana-Champaign
- Last refreshed: 7 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06243016.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing