Last reviewed · How we verify
NCT06239974
Vericiguat in Patients With Coronary Microvascular Dysfunction Causing Stable Chest Pain (V-COM)
NA trial testing Vericiguat in Chest Pain in 94 participants. Currently enrolling.
31 August 2027
Quick facts
| Lead sponsor | The University of Hong Kong |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | diagnostic |
| Enrollment | 94 |
| Start date | 1 September 2024 |
| Primary completion | 31 August 2027 |
| Estimated completion | 31 August 2027 |
| Sites | 1 location across Hong Kong |
Drugs / interventions tested
- Vericiguat (VERICIGUAT) — full drug profile →
- Stress Cardiac Magnetic Resonance
Conditions studied
- Chest Pain — all drugs for Chest Pain →
Sponsor
The University of Hong Kong
Who can join
Adults 40 to 75, any sex, with Chest Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a randomised controlled trial to determine the effectiveness of Vericiguat to improve stress myocardial blood flow (MBF) and myocardial perfusion reserve as measured by cardiac magnetic resonance (CMR) imaging.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Focusing on microvascular function in heart failure with preserved ejection fraction.
Velollari O, Rommel KP, Kresoja KP, Lurz P, et al · · 2025 · cited 4× · PMID 39804445 · DOI 10.1007/s10741-024-10479-7
Verify or expand the search:
- PubMed search for NCT06239974
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Vericiguat
Trials testing the same drug.
- NCT07405944 — Vericiguat and Reverse Remodeling Indices in Heart Failure · Phase 4 · recruiting
- NCT07047547 — A Study of Real-world Events of Vericiguat in Patients With Chronic Kidney Disease and Heart Failure · NA · recruiting
- NCT06812546 — Efficacy and Safety of Early Initiation of Vericiguat in Heart Failure After Acute Myocardial Infarction · Phase 4 · not yet recruiting
- NCT06415227 — The Impact of Vericiguat on Microvascular Function in Patients with Documented Vasospastic Angina Pectoris · Phase 2 · not yet recruiting
- NCT06671990 — The CardioMEMS Vericiguat Heart Failure Trial · Phase 4 · not yet recruiting
Other recruiting trials for Chest Pain
Currently open trials in the same condition.
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- NCT06520150 — Evaluation of the Effectiveness of Two Methods of Regional Anesthesia During S-ICD Implantation Procedure. · NA · recruiting
- NCT07435168 — CHEST-CA: Study of Chest Pain and Hidden Cardiac Amyloidosis · NA · recruiting
- NCT06670768 — Myocardial Perfusion Quantification With SPECT Using Multi-Pinhole Collimator Compared to Photon-Counting Coronary CTA · NA · recruiting
Other The University of Hong Kong trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06239974 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The University of Hong Kong
- Last refreshed: 7 October 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06239974.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing