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NCT06236503: tDCS-GCA
Effect of Transcranial Direct Current Stimulation in Altered States of Consciousness
NA trial testing Real Stimulation in Neurologic Disorder in 100 participants. Currently enrolling.
20 December 2025
Quick facts
| Lead sponsor | IRCCS Centro Neurolesi Bonino Pulejo |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 100 |
| Start date | 10 January 2023 |
| Primary completion | 20 December 2025 |
| Estimated completion | 30 December 2025 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Real Stimulation
- Placebo Stimulation
Conditions studied
- Neurologic Disorder — all drugs for Neurologic Disorder →
- Brain Injuries — all drugs for Brain Injuries →
Sponsor
IRCCS Centro Neurolesi Bonino Pulejo — full company profile →
Who can join
Adults 18 to 75, any sex, with Neurologic Disorder or Brain Injuries. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Transcranial Direct Current Stimulation (tDCS) is a non-invasive, painless brain stimulation treatment that uses low-intensity direct electrical currents to stimulate specific parts of the brain. Transcranial Direct Current Stimulation (tDCS) can both facilitate anodic stimulation and inhibit cathodic stimulation specific brain areas since many neurological and psychiatric disorders are connected to hypoactivity or hyperactivity in specific areas of the nervous system. This phenomenon is based on two processes: the reorganization of functional neural circuits and their reconstruction. In light of the studies mentioned above, it is presumed that Transcranial Direct Current Stimulation (tDCS) can be a valuable tool to facilitate the process of neuroplasticity in individuals with chronic neurological diseases and in patients with impaired consciousness following severe brain injury. A previous study demonstrated that a single session of transcranial direct current electrical stimulation could temporarily improve signs of consciousness in patients in a minimally conscious state (MCS)
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Cognitive and neurophysiological effects of bilateral tDCS neuromodulation in patients with minimally conscious state.
Gangemi A, Impellizzeri F, Fabio RA, Suriano R, et al · · 2025 · cited 2× · PMID 40274956 · DOI 10.1038/s41598-025-99591-8
Verify or expand the search:
- PubMed search for NCT06236503
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other IRCCS Centro Neurolesi Bonino Pulejo trials
Trials by the same sponsor.
- NCT07385508 — Neurorehabilitation in Patients With Disorders of Consciousness: Multidimensional Ambispective Study on the Impact of Si · not yet recruiting
- NCT07358962 — Mild Cognitive Impairment and Psychopathology · not yet recruiting
- NCT07321080 — Central Sensitisation in Nociceptive and Neuropathic Pain · active not recruiting
- NCT07268768 — PERSONOLOGICAL STRUCTURE, COGNITIVE FUNCTIONS AND CENTRAL SENSITIZATION IN HEADACHE · recruiting
- NCT07422324 — Multidimensional Assessment of Mental Health in Adolescence. · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06236503 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by IRCCS Centro Neurolesi Bonino Pulejo
- Last refreshed: 1 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06236503.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing