Deuterium Metabolic MRI and [18F]FDG PET for Assessment of Treatment Response Following Radioembolization (DEPLETE)

NCT06232889 NA RECRUITING

Radioembolization, also known as Selective Internal Radiation Therapy (SIRT), is a liver-directed therapy for patients suffering from hepatic metastases. As SIRT is a liver-directed treatment, only patients with liver-only or liver-dominant disease are eligible for treatment. FDG-PET/CT is known to outperform conventional anatomical imaging modalities (CT or MRI) for treatment response assessment, also being of prognostic value. Subsequently following SIRT, patients are restaged with FDG-PET/CT. However, optimal timing of restaging following treatment is unknown (most commonly after 1 or 3 months, according to local institutional guidelines). More importantly, intrinsic resolution of FDG-PET/CT limits its utility in patients with small metastases, as image quality is worsened by high background noise, due to physiologic FDG uptake / metabolism in normal liver parenchyma. Additionally, FDG as radiopharmaceutical increases additional radiation burden to patients. This study will investigate the potential of metabolic MRI (7T MRI), non-invasively imaging metabolites using X-nuclei (e.g. 31P MRSI) and more importantly, the application of Deuterium Metabolic Imaging (DMI) with non-radioactive deuterated glucose, as a potential alternative over FDG-PET/CT.

Details

Lead sponsor	UMC Utrecht
Phase	NA
Status	RECRUITING
Enrolment	15
Start date	Mon Jan 01 2024 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Fri Jan 01 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Fluorodeoxyglucose F18
• Phosphoric Monoester Hydrolases
• Phosphoric Diester Hydrolases

Interventions

• Deuterium Glucose Metabolic Imaging with MRI spectroscopy

Countries

Netherlands