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NCT06226103
Effectiveness Of Computer-Based Cognitive Training in Age-Related Cognitive Decline
NA trial testing Aerobic Exercise and Computerized Cognitive Training in Age-related Cognitive Decline in 60 participants. Completed in 12 February 2025.
25 December 2024
Quick facts
| Lead sponsor | University of Jazan |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 15 January 2024 |
| Primary completion | 25 December 2024 |
| Estimated completion | 12 February 2025 |
| Sites | 1 location across Saudi Arabia |
Drugs / interventions tested
- Aerobic Exercise and Computerized Cognitive Training
- Conventional Exercises and Brain health lectures
Conditions studied
- Age-related Cognitive Decline — all drugs for Age-related Cognitive Decline →
Sponsor
University of Jazan
Who can join
Adults 60 to 85, any sex, with Age-related Cognitive Decline. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Background: Ageing is frequently accompanied by physiological changes that might result in a deterioration in physical and cognitive abilities, which frequently leads to institutionalization or the loss of autonomy. Mild cognitive impairment (MCI) is an intermediate state between normal cognitive aging and early dementia, the optimal period to intervene with preventive strategies and early treatments. Thus, the current study intends to investigate the effects of aerobic and computer-based cognitive training on age-related cognitive decline. Methods: This is a single-blinded, randomized controlled trial. Elderly patients with mild cognitive impairment (n = 60) will be randomized to 2 arms and treated for 12 weeks: arm 1 (aerobic exercise and computerized cognitive training) and arm 2 (Placebo; will not receive any intervention). Outcome measure used were Montreal Cognitive Assessment (MOCA) test, Barthel Index (BI) and short form survey-12 (SF-12). Statistical Analysis: To compare the baseline characteristics and outcome variables between the two groups, independent t-tests was employed. A two-way repeated measures ANOVA was utilized to determine the interaction effect of time (baseline, post-treatment, and follow-up) and group (intervention vs. control) on the outcome measures.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effects of aerobic exercise and computer-based cognitive training on cognition, functional independence, quality of life, and salivary cortisol levels in older adults with mild cognitive impairment: a randomized trial.
Raheem Khan A, Aafreen A, Khan A, Ganesh GS, et al · · 2026 · PMID 41918619 · DOI 10.3389/fnagi.2026.1776069
Verify or expand the search:
- PubMed search for NCT06226103
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06226103 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Jazan
- Last refreshed: 29 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06226103.
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