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NCT06223672: EFFECT
Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study
NA trial testing Walnuts in Cognitive Decline in 88 participants. Currently enrolling.
31 December 2025
Quick facts
| Lead sponsor | Ohio State University |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 88 |
| Start date | 7 February 2024 |
| Primary completion | 31 December 2025 |
| Estimated completion | 31 May 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Walnuts — full drug profile →
- Simply White Diary-free chocolate bar
Conditions studied
- Cognitive Decline — all drugs for Cognitive Decline →
- Cognitive Impairment — all drugs for Cognitive Impairment →
Sponsor
Ohio State University
Who can join
Adults 40 to 75, any sex, with Cognitive Decline or Cognitive Impairment. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The proposed research is a randomized crossover trial designed to assess changes in postprandial cognitive function and the gut-brain axis in adults with subjective cognitive complaints who consume 1 study snack per day for 1 week.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effects of Walnuts on Postprandial Cognitive Function in Adults With Subjective Cognitive Impairment: Protocol for a Randomized Crossover Trial.
Zarich S, Cole RM, Fairchild K, Spakowicz D, et al · · 2025 · PMID 41418290 · DOI 10.2196/82032
Verify or expand the search:
- PubMed search for NCT06223672
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Walnuts
Trials testing the same drug.
- NCT05195970 — Walnuts and Colon Health · NA · completed
- NCT04918537 — Analysis of Microbiota Variations in Industry Workers Working Different Shifts and Impact of a Nutritional Intervention · NA · unknown
- NCT04066816 — Ellagic Acid, Urolithin and Colonic Microbial Communities Affected by Walnut Consumption · NA · completed
- NCT03334175 — Walnuts to Achieve Lasting NUTrition to Prevent Diabetes · Phase 1, PHASE2 · completed
- NCT03318042 — Genotype, Metabotype and Diet in a Cohort of Children and Adolescents From the Southeast of Spain. · NA · completed
Other recruiting trials for Cognitive Decline
Currently open trials in the same condition.
- NCT07220694 — Effects of Sabroxy® Supplementation on Insulin Resistance and Cognitive Function in Adults With Mild Cognitive Impairmen · NA · recruiting
- NCT07394504 — Effects of Turning Based Dual Task Training on Balance and Mild Cognitive Impairment in Diabetic Peripheral Neuropathy · NA · recruiting
- NCT07127965 — Exercise Adherence and Cognitive Decline: Phase 2 · NA · recruiting
- NCT07151365 — Plant-based Diets and Healthy Aging · recruiting
- NCT07399418 — TRIAD - Tracking Risk in Integrated Alzheimer's Diagnostics. · recruiting
Other Ohio State University trials
Trials by the same sponsor.
- NCT06542458 — Under-Represented Communities Diagnosed With SCD or MCI Through Tele-Cog · not yet recruiting
- NCT07217548 — Solving Stigma Through POV Simulation: Enhancing Pharmacist Empathy-based Practices With Sickle Cell Disease Patients · NA · enrolling by invitation
- NCT07215221 — Implementation of TBI-RECOVER in Substance Use Treatment · NA · not yet recruiting
- NCT07278427 — Reducing Parental Substance Use and Enhancing Family Resilience Among Rural Families Through Ohio START · recruiting
- NCT07490444 — Metric-Optimized Spectacle Prescriptions for Children With Down Syndrome · Phase 2 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06223672 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ohio State University
- Last refreshed: 8 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06223672.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing