NCT06223243

The Effect of Stingless Bee Honey Mouthrinse on Dental Plaque Accumulation

Completed NA Last updated 25 January 2024

What this trial tests

NA trial testing Stingless bee honey mouthrinse in Plaque Accumulation in 30 participants. Completed in 1 January 2024.

Timeline

1 March 2023

Primary endpoint
1 September 2023

1 January 2024

Quick facts

Lead sponsor	Universiti Sains Islam Malaysia
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	prevention
Enrollment	30
Start date	1 March 2023
Primary completion	1 September 2023
Estimated completion	1 January 2024
Sites	1 location across Malaysia

Drugs / interventions tested

• Stingless bee honey mouthrinse
• normal saline mouthrinse
• chlorhexidine mouthrinse — full drug profile →

Conditions studied

• Plaque Accumulation — all drugs for Plaque Accumulation →
• Patient Acceptance — all drugs for Patient Acceptance →

Sponsor

Universiti Sains Islam Malaysia

Who can join

Adults 18 to 40, any sex, with Plaque Accumulation or Patient Acceptance. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Mouthrinses are recommended as a complement to mechanical methods in oral hygiene procedures to prevent and control periodontal diseases. Chlorhexidine mouthrinse has been used as a chemical plaque control agent for many years. However, in spite of its potent antimicrobial and antiplaque properties, there have been various reports of the undesirable adverse effects of chlorhexidine mouthrinse. This creates the need to look for an alternative mouthrinse that can also help in controlling plaque.

Stingless bee honey is an alternative agent which is increasingly known for its better properties and easily available compared to other types of honey. It has been reported to have many benefits for the oral cavity such as antibacterial, anti-inflammatory, and healing properties which makes it a potential therapeutic agent in periodontal therapy. However, there is a lack of clinical studies showing its efficacy in plaque control as a mouthrinse.

Hence, this study aims to investigate the ability of stingless bee honey mouthrinse to reduce plaque accumulation. This will be done through a randomised clinical trial whereby subjects will be prescribed with a mouthrinse formulation and instructed to refrain from any tooth cleaning procedure. The patient's plaque score will be recorded before and after the intervention to measure the effectiveness of the mouthrinse.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Effects of a Stingless Bee Honey Mouth Rinse on Dental Plaque Accumulation: A Randomised Clinical Trial.
   Reduan MH, Zulkaflee NS, Sabarudin MA, Mat Baharin NH, et al · · 2025 · PMID 40688909 · DOI 10.7759/cureus.86307
2. The Effect of Stingless Bee Honey Mouthrinse on Dental Plaque Accumulation: A Randomised Clinical Trial
   Hayei NAA, Reduan MH, Zulkaflee NS, Baharin NHM, et al · · 2024 · DOI 10.21203/rs.3.rs-4649855/v1