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NCT06222645
PPG vs. ICG in Gastrointestinal Resections
NA trial testing ICG fluorescence imaging technology in Anastomosis in 200 participants. Currently enrolling.
30 April 2026
Quick facts
| Lead sponsor | Saint Petersburg State University, Russia |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 200 |
| Start date | 1 November 2023 |
| Primary completion | 30 April 2026 |
| Estimated completion | 31 May 2026 |
| Sites | 3 locations across China, Russia |
Drugs / interventions tested
- ICG fluorescence imaging technology — full drug profile →
- Imaging Photoplethysmography System
Conditions studied
- Anastomosis — all drugs for Anastomosis →
- Perfusion — all drugs for Perfusion →
- Postoperative Complications — all drugs for Postoperative Complications →
- Gastrointestinal Neoplasms — all drugs for Gastrointestinal Neoplasms →
Sponsor
Saint Petersburg State University, Russia
Who can join
18 and older, any sex, with Anastomosis or Perfusion. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This randomized controlled trial compares a novel optical technique against the standard of care for assessing tissue perfusion in gastrointestinal surgery. Participants are randomized to receive either intraoperative imaging photoplethysmography (iPPG) or indocyanine green (ICG) fluorescence imaging. In the ICG group, the fluorescence data are comprehensively analyzed in two distinct ways: (1) Qualitative Assessment: real-time visual interpretation of the angiogram flow by the operating surgeon; and (2) Quantitative Assessment: software-based analysis of fluorescence kinetics (e.g., time-to-peak, maximum intensity) to generate objective perfusion parameters. The study aims to determine the agreement between the iPPG-based evaluations and both the qualitative and quantitative dimensions of the ICG standard.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06222645
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06222645 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Saint Petersburg State University, Russia
- Last refreshed: 18 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06222645.
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