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NCT06221722
Predicting Treatment Outcomes in Refractory Constipation Through Brain Connectivity Evaluation
trial testing BOLD-fMRI in Constipation - Functional in 150 participants. Currently enrolling.
1 September 2025
Quick facts
| Lead sponsor | Xijing Hospital of Digestive Diseases |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 150 |
| Start date | 1 November 2023 |
| Primary completion | 1 September 2025 |
| Estimated completion | 1 September 2026 |
| Sites | 3 locations across China |
Drugs / interventions tested
- BOLD-fMRI
- Regular treatment of functional constipation — full drug profile →
- fluoxetine (fluoxetine) — full drug profile →
Conditions studied
- Constipation - Functional — all drugs for Constipation - Functional →
- Refractory Constipation — all drugs for Refractory Constipation →
- Fluoxetine — all drugs for Fluoxetine →
- fMRI — all drugs for fMRI →
Sponsor
Xijing Hospital of Digestive Diseases
Who can join
Adults 18 to 45, any sex, with Constipation - Functional or Refractory Constipation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this observational study is to identify the characteristics of brain functional connectivity in refractory constipation and fluoxetine-sensitive patients. The main questions it aims to answer are: * Investigating the alterations in brain functional connectivity in patients with refractory constipation and fluoxetine-sensitive patients * Assessing the predictive value of brain functional connectivity regarding the efficacy of fluoxetine and standard protocol treatments for constipation. Participants will receive: * Standard physiological and psychological assessments of constipation * BOLD-fMRI tests * Standard protocol and fluoxetine treatment If there is a comparison group: Researchers will compare: Refractory group/Fluoxetine sensitive group to see the specific brain alterations.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06221722
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other Xijing Hospital of Digestive Diseases trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06221722 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Xijing Hospital of Digestive Diseases
- Last refreshed: 24 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06221722.
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