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NCT06221488: THWART-TB
Testing Health Workers At Risk to Advance Our Understanding of TB Infection
trial testing TB infection testing in Tuberculosis in 300 participants. Currently enrolling.
31 December 2028
Quick facts
| Lead sponsor | Beth Israel Deaconess Medical Center |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 300 |
| Start date | 15 January 2024 |
| Primary completion | 31 December 2028 |
| Estimated completion | 31 December 2029 |
| Sites | 1 location across South Africa |
Drugs / interventions tested
- TB infection testing
Conditions studied
- Tuberculosis — all drugs for Tuberculosis →
- Tuberculosis Infection — all drugs for Tuberculosis Infection →
Sponsor
Beth Israel Deaconess Medical Center
Who can join
Adults 18 to 100, any sex, with Tuberculosis or Tuberculosis Infection. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
It has been estimated that 1.7 billion people have tuberculosis (TB) infection; yet current tests are unable to predict which people are at highest risk of developing TB disease, which can be life-threatening. THWART-TB is a prospective longitudinal cohort study of health workers (HWs) in Cape Town, South Africa, where our preliminary data reveals HWs have a high annual TB infection risk (34%). This cohort, who will undergo frequent serial evaluation (every 3 months) with a combination of novel assays never previously evaluated together, presents a unique opportunity to evaluate immune responses at the time of initial infection and to characterize the dynamic profile of these immune responses over time in a high-risk population. The knowledge generated will improve our understanding of TB infection and help to identify which people exposed to TB may remain at risk, enabling us to better target preventive strategies.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06221488
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06221488 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Beth Israel Deaconess Medical Center
- Last refreshed: 23 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06221488.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing