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NCT06213493: BACE1AS-HF
Bace1as Role in Heart Failure (BACE1AS-HF)
trial testing measurement of RNAs in Heart Failure in 630 participants. Completed in 30 November 2024.
30 November 2024
Quick facts
| Lead sponsor | IRCCS Policlinico S. Donato |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 630 |
| Start date | 12 March 2021 |
| Primary completion | 30 November 2024 |
| Estimated completion | 30 November 2024 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- measurement of RNAs
Conditions studied
- Heart Failure — all drugs for Heart Failure →
- Acute Coronary Syndrome — all drugs for Acute Coronary Syndrome →
Sponsor
IRCCS Policlinico S. Donato
Who can join
Adults 18 to 75, any sex, with Heart Failure or Acute Coronary Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The objective of this project is 1) to explore the clinical relevance of BACE1-AS and BACE1 as therapeutic targets and 2) to evaluate their potentiality as biomarkers in ischemic heart failure (HF). The first aim will be studied by validating in left ventricle biopsies in patients with post-ischemic heart failure the transcriptome and DNA methylation status data obtained in cell lines where the expression of BACE1-AS has been modulated. The investigation of BACE1-AS and BACE1 as biomarkers will be obtained by using peripheral blood mononuclear cells (PBMCs) from patients with acute coronary syndrome (ACS) treated with percutaneous angioplasty (PCI) procedure and undergoing to left ventricular remodeling. Furthermore, PBMCs from patients with chronic ischemic HF recruited from the Istituti Clinici Scientifici Maugeri Pavia will be also used. From the data obtained from these patients and from non-decompensated subjects, the levels of BACE1-AS and BACE1 in the blood will be measured and correlated with each other and with β-amyloid levels (βA), as well as with clinically relevant parameters.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Noncoding RNA Contribution to Aging and Lifespan.
Ugalde AP, Roiz-Valle D, Moledo-Nodar L, Caravia XM, et al · · 2024 · cited 10× · PMID 38394352 · DOI 10.1093/gerona/glae058 -
Molecular Diagnostics in Heart Failure: From Biomarkers to Personalized Medicine.
Țica O, Țica O. · · 2025 · cited 8× · PMID 40722556 · DOI 10.3390/diagnostics15141807 -
The Relevance of the Accurate Annotation of Micro and Long Non-Coding RNA Interactions for the Development of Therapies.
Panni S. · · 2025 · cited 2× · PMID 40149414 · DOI 10.3390/genes16030262
Verify or expand the search:
- PubMed search for NCT06213493
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of measurement of RNAs
Trials testing the same drug.
- NCT03268135 — Heart Failure and Aortic Stenosis Transcriptome · recruiting
Other recruiting trials for Heart Failure
Currently open trials in the same condition.
- NCT06118983 — Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe (I-TRANSFER-HF) · NA · recruiting
- NCT07496372 — Efficacy and Safety of Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Injection (HiCM-188) in Advanced Heart · Phase 3 · recruiting
- NCT07527156 — Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure · Phase 4 · recruiting
- NCT07263035 — Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure · Phase 4 · recruiting
- NCT07531966 — Vascular Complications After Kidney Transplantation · recruiting
Other IRCCS Policlinico S. Donato trials
Trials by the same sponsor.
- NCT07295522 — Pharmacological Optimization in Prevention in Heart Failure: A Sex-gap? · Phase 4 · not yet recruiting
- NCT07169669 — Multicentre Longitudinal Study of Bone Mineralisation Characteristics in Marfan Syndrome and Ehlers-Danlos Syndrome · not yet recruiting
- NCT07455292 — Phenotyping Left Ventricle Failure With Hemodynamic Biomarkers From 4D Flow Magnetic Resonance Imaging · NA · recruiting
- NCT07402161 — The Signature of Alzheimer's Disease in Subjective Cognitive Decline · recruiting
- NCT06294119 — Multivariate Approach to the Numerical Assessment of Cortical - Autonomic - VAscular Dynamic Interplay · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06213493 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by IRCCS Policlinico S. Donato
- Last refreshed: 30 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06213493.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing