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NCT06207422: ChronicPA-PAIN
The Effects of a Moderate Intensity Training Program Versus a High Intensity Training Program on Central Pain Processing
NA trial testing Moderate intensity training program in Healthy in 30 participants. Terminated before completion.
23 August 2024
Quick facts
| Lead sponsor | University Ghent |
|---|---|
| Phase | NA |
| Status | Terminated |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 30 |
| Start date | 27 November 2023 |
| Primary completion | 23 August 2024 |
| Estimated completion | 23 August 2024 |
| Sites | 1 location across Belgium |
Drugs / interventions tested
- Moderate intensity training program
- High intensity training program
Conditions studied
- Healthy — all drugs for Healthy →
Sponsor
University Ghent
Who can join
Adults 18 to 55, any sex, with Healthy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Previous studies have shown that healthy individuals who take more steps per day and who spend more time on moderate- to vigorous-intensity activities exhibit better pain inhibition and less pain facilitation. Furthermore, exercise training (i.e., exercise performed over a number of sessions) can result in reduced pain sensitivity (increased pressure pain threshold). However, the optimal exercise prescription required to achieve pain sensitivity reduction is currently unclear. The next step is to determine experimentally whether increasing physical fitness will lead to positive effects on central pain processing (i.e., pain sensitivity, pain modulation, spinal nociception). The aim of this study is to examine the effects of two exercise programs on central pain processing in healthy sedentary individuals. In case of positive effects, this would provide a rationale for the future to investigate this in chronic pain patients with impaired pain modulation.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The influence of a moderate versus high intensity training program on central pain processing: a pilot feasibility study.
Billens A, Hamelink T, Meeus M, Van Oosterwijck J. · · 2026 · PMID 41649235 · DOI 10.1080/17581869.2026.2626256
Verify or expand the search:
- PubMed search for NCT06207422
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06207422 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Ghent
- Last refreshed: 8 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06207422.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing