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NCT06207331
Effects of Atomized Dexmedetomidine on Lung Function in Patients With Chronic Obstructive Pulmonary Disease
NA trial testing Dexmedetomidine 0.5 μg/kg in Respiratory Function Tests in 6 participants. Terminated before completion.
30 June 2024
Quick facts
| Lead sponsor | The Second Affiliated Hospital of Chongqing Medical University |
|---|---|
| Phase | NA |
| Status | Terminated |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 6 |
| Start date | 28 October 2023 |
| Primary completion | 30 June 2024 |
| Estimated completion | 30 June 2024 |
| Sites | 1 location across China |
Drugs / interventions tested
- Dexmedetomidine 0.5 μg/kg
- Dexmedetomidine 1 μg/kg
- Saline
Conditions studied
- Respiratory Function Tests — all drugs for Respiratory Function Tests →
- Chronic Obstructive Pulmonary Disease — all drugs for Chronic Obstructive Pulmonary Disease →
- Dexmedetomidine — all drugs for Dexmedetomidine →
Sponsor
The Second Affiliated Hospital of Chongqing Medical University
Who can join
Adults 40 to 80, any sex, with Respiratory Function Tests or Chronic Obstructive Pulmonary Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Studies have shown that intravenous infusion and nebulized dexmedetomidine can improve lung function in mechanically ventilated patients, including those with preoperative COPD, exerting lung protection. However, these studies are based on mechanical ventilation patients under general anesthesia, and more intuitive research is needed on whether dexmedetomidine can also exercise pulmonary precaution in awake patients. Pulmonary function monitoring is the most direct way to evaluate changes in lung function in awake patients. Portable pulmonary function machines can assess lung function in a variety of settings. In addition, compared with intravenous administration, nebulized inhalation administration directly acts on the mucosa of the respiratory tract, does not involve invasive operations, and has higher safety and comfort. Therefore, this study intends to use portable pulmonary function instruments and non-invasive ambulatory respiratory monitors to evaluate the effect of nebulized dexmedetomidine on lung function in COPD patients to guide the perioperative management of COPD patients.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06207331
- Europe PMC full search
- ASCO Meeting Library
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Related trials
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Trials testing the same drug.
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Other recruiting trials for Respiratory Function Tests
Currently open trials in the same condition.
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- NCT06359145 — Prediction of COPD Severity Using Electrical Impedance Tomography · recruiting
- NCT05459116 — Visualization of Inspiratory Effort and Respiratory Mechanics to Promote Lung- and Diaphragm Protective Ventilation · NA · recruiting
Other The Second Affiliated Hospital of Chongqing Medical University trials
Trials by the same sponsor.
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- NCT07339644 — Functional Lung Avoidance Radiotherapy Guided by 4DCT Pulmonary Ventilation Function Imaging: A Prospective Single-arm C · NA · recruiting
- NCT07048782 — Development and Validation of a Risk Prediction Model for Postoperative Visceral Pain in Abdominal Surgery Patients · not yet recruiting
- NCT07033949 — Effect of Green Light Exposure at Different Times on the Pain of Subjects · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06207331 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The Second Affiliated Hospital of Chongqing Medical University
- Last refreshed: 31 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06207331.
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