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NCT06189066: LOCUS
Long COVID Ultrasound Trial
NA trial testing Splenic Ultrasound in Long Covid in 15 participants. Completed in 24 July 2025.
24 July 2024
Quick facts
| Lead sponsor | SecondWave Systems Inc. |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | device feasibility |
| Enrollment | 15 |
| Start date | 3 January 2024 |
| Primary completion | 24 July 2024 |
| Estimated completion | 24 July 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Splenic Ultrasound
Conditions studied
- Long Covid — all drugs for Long Covid →
Sponsor
SecondWave Systems Inc.
Who can join
Adults 18 to 65, any sex, with Long Covid. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The research objective is to assess the safety and potential efficacy of spleen ultrasound stimulation as an intervention for Long COVID in a pilot study. Specific Aims include: * Measure Long COVID disease activity before, during and after an 8-week course of spleen-directed daily ultrasound stimulation. * Measure molecular correlates of Long COVID disease activity before, during and after an 8-week course of spleen-directed daily ultrasound stimulation. * Track adverse events throughout the study to assess safety of the ultrasound intervention.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Targeted spleen modulation: a novel strategy for next-generation disease immunotherapy.
Dong W, Li Y, Fei Q, Li S, et al · · 2025 · cited 16× · PMID 40225564 · DOI 10.7150/thno.111116
Verify or expand the search:
- PubMed search for NCT06189066
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Splenic Ultrasound
Trials testing the same drug.
- NCT05417854 — Ultrasound Treatment for Rheumatoid Arthritis Study [ULTRA Study] · NA · completed
- NCT04854798 — UNITE Study (UMN-SW) for COVID-19 · NA · completed
- NCT04803409 — UNITE Study (UCSD-SW) for COVID-19 · NA · unknown
Other recruiting trials for Long Covid
Currently open trials in the same condition.
- NCT06522750 — Periodic Fasting for Treatment of Long Covid in Adults: a Pilot Study · NA · recruiting
Other SecondWave Systems Inc. trials
Trials by the same sponsor.
- NCT05417854 — Ultrasound Treatment for Rheumatoid Arthritis Study [ULTRA Study] · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06189066 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by SecondWave Systems Inc.
- Last refreshed: 7 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06189066.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing