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NCT06188039: PRESCIENCE
Superior Vena Cava Collapsibility Index for Predicting Fluid Responsiveness During High-risk Non-cardiac Surgery
NA trial testing Superior vena cava collapsibility index in Surgery in 150 participants. Completed in 18 November 2025.
17 November 2025
Quick facts
| Lead sponsor | Uniwersytecki Szpital Kliniczny w Opolu |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 150 |
| Start date | 3 January 2024 |
| Primary completion | 17 November 2025 |
| Estimated completion | 18 November 2025 |
| Sites | 1 location across Poland |
Drugs / interventions tested
- Superior vena cava collapsibility index
- PEEP elevation
Conditions studied
- Surgery — all drugs for Surgery →
- Fluid Responsiveness — all drugs for Fluid Responsiveness →
- Transesophageal Echocardiography — all drugs for Transesophageal Echocardiography →
Sponsor
Uniwersytecki Szpital Kliniczny w Opolu — full company profile →
Who can join
18 and older, any sex, with Surgery or Fluid Responsiveness. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this prospective study is to validate the superior vena cava collapsibility index (SVC-CI) as a predictor of fluid responsiveness during laparotomy and open aortic surgery. The SVC-CI and patients' response to fluid will be assessed based on transesophageal echocardiography. The study has three arms, in order to validate SVC-CI under the conditions of laparotomy, aortic cross clamping and high PEEP levels. One of the study arms will be an active comparator arm. The data obtained from this study may help physicians guide intraoperative fluid therapy in a more efficient manner, in order to decrease perioperative mortality.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06188039
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Uniwersytecki Szpital Kliniczny w Opolu trials
Trials by the same sponsor.
- NCT06174610 — Changes of Renal Resistive Index in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy. · recruiting
- NCT06729268 — Fluid Responsiveness Tests in Critically Ill Patients During Admission to the Intensive Care Unit · completed
- NCT05657678 — Vitamin D3 Supplementation in Critically Ill Patients Undergoing CRRT · Phase 4 · recruiting
- NCT03412422 — Ultrasound Assessment of Changes in the Diameter of the Common Carotid Artery After Increasing the Preload of the Heart · withdrawn
- NCT03873675 — Parathyroid Hormone Kinetics During CRRT · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06188039 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Uniwersytecki Szpital Kliniczny w Opolu
- Last refreshed: 6 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06188039.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing