Last reviewed · How we verify
NCT06180447
Peri-conceptional or Pregnancy Exposure of Vaccination and the Risk of Adverse Pregnancy Outcomes
trial testing Hepatitis B vaccine, rabies vaccine, HPV vaccine, influenza vaccine in Vaccine Adverse Reaction in 150,000 participants. Participants enrolled and being followed up; not accepting new ones.
31 December 2024
Quick facts
| Lead sponsor | Sun Xin |
|---|---|
| Status | Active, enrolled |
| Study type | OBSERVATIONAL |
| Enrollment | 150,000 |
| Start date | 1 January 2024 |
| Primary completion | 31 December 2024 |
| Estimated completion | 30 March 2025 |
| Sites | 1 location across China |
Drugs / interventions tested
- Hepatitis B vaccine, rabies vaccine, HPV vaccine, influenza vaccine — full drug profile →
Conditions studied
- Vaccine Adverse Reaction — all drugs for Vaccine Adverse Reaction →
Sponsor
Sun Xin — full company profile →
Who can join
Adults 14 to 65, female only, with Vaccine Adverse Reaction. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Uing data from a population based cohort in China, we will conduct retrospective cohort study to evaluate the risk of vaccine (e.g., HPV/influenza/rabies vaccine) administered during pregnancy (especially during first trimester) for adverse pregnancy outcomes (e.g., birth defects, preterm birth and low birth weight)
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Peri-conception human papillomavirus vaccination exposure and risk of birth defects: a population-based retrospective cohort study
Guo J, Zhao P, Liu C, Liao M, et al · · 2025 · DOI 10.22541/au.174103926.60657229/v1 -
Peri-Conception Human Papillomavirus Vaccination Exposure and Risk of Birth Defects: A Population-Based Retrospective Cohort Study.
Guo J, Zhao P, Liu C, Liao M, et al · · 2025 · PMID 40984047 · DOI 10.1002/pds.70222 -
Peri-conception human papillomavirus vaccination exposure and risk of birth defects: a population-based retrospective cohort study
Guo J, Xiong Y, Zhao P, Liu C, et al · · 2024 · DOI 10.21203/rs.3.rs-5294774/v1
Verify or expand the search:
- PubMed search for NCT06180447
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Vaccine Adverse Reaction
Currently open trials in the same condition.
- NCT05898464 — Immunogenicity and Safety of Recombinant Zoster Vaccine in People Living With HIV · Phase 4 · active not recruiting
- NCT06286488 — Effectiveness and Tolerability of Influenza Vaccine in Patients at Risk for Severe and Complicated Influenza · Phase 4 · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06180447 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Sun Xin
- Last refreshed: 7 May 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06180447.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing