NCT06179784

Personalising Psychotherapy for Chronic Primary Pain Using Network Analysis

Completed NA Last updated 22 December 2025

What this trial tests

NA trial testing Cognitive Behaviour Therapy including third-wave in Chronic Primary Pain in 12 participants. Completed in 8 August 2025.

Timeline

17 November 2023

Primary endpoint
8 August 2025

8 August 2025

Quick facts

Lead sponsor	Prof. Dr. Julia Glombiewski
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	12
Start date	17 November 2023
Primary completion	8 August 2025
Estimated completion	8 August 2025
Sites	1 location across Germany

Drugs / interventions tested

• Cognitive Behaviour Therapy including third-wave

Conditions studied

• Chronic Primary Pain — all drugs for Chronic Primary Pain →

Sponsor

Prof. Dr. Julia Glombiewski

Who can join

18 and older, any sex, with Chronic Primary Pain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this single case experimental design study with multiple baselines is to use network analysis to personalise cognitive behaviour therapy for chronic primary pain (CPP) and base the selection of individual treatment targets and interventions on data to avoid cognitive biases of the clinicians. The main questions it aims to answer are:

* Is the study procedure accepted by and feasible for CPP patients as well as their therapists?
* Does the personalised psychotherapy with databased clinical decisionmaking lead to significant improvement?

Participants will go through several study phases:

* Pretest and informational meeting with study management
* Baseline 1: answering a questionnaire six times a day for 21 days in daily life on their mobilephone (EMA); this data will be used for the calculation of a network for each participant, that in turn will be used to select the treatment target and according treatment intervention as suggested by an algorithmic decisiontool
* Probatory therapy phase: three weekly sessions with therapist; questionnaire three times a week
* Baseline 2: questionnaire three times a week
* Therapy phase: up to ten sessions with therapist; questionnaire three times a week
* Post phase: posttest, two weeks of three weekly assessments, then another 21 days EMA; two monthly booster sessions with therapist
* Follow-up: posttest and meeting with study management

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. How to personalise cognitive-behavioural therapy for chronic primary pain using network analysis: study protocol for a single-case experimental design with multiple baselines.
   Hofmann VE, Glombiewski JA, Kininger F, Scholten S. · · 2024 · cited 2× · PMID 39627123 · DOI 10.1136/bmjopen-2024-089319