Outcome of Regenerative Endodontic Procedure and Root Canal Treatment for the Management of Apical Periodontitis

NCT06179433 NA UNKNOWN

Background Root canal therapy is the primary treatment of choice for necrotic mature teeth with periapical lesions (PRLs), which does not restore the tooth's vitality. Provided that injectable platelet-rich fibrin (i-PRF) has shown promising results in regenerative medicine as a novel platelet concentration, the purpose of this study is to ascertain whether i-PRF, as opposed to blood clot (BC), can serve as a biological scaffold, thereby expanding the indications for regenerative endodontic procedures (REPs) in mature teeth. Novelty There is no study available that has evaluated the outcome of REP in the necrotic mature mandibular molars with periapical lesions. Furthermore, the efficacy of novel i-PRF as a scaffold in REPs remains to be explored. Objectives To evaluate and compare the outcome of REPs in comparison to conventional RCT in necrotic mature molars with PRLs and to evaluate the efficacy of i-PRF and BC in REP as a scaffold. Secondary objective is to evaluate pain for first postoperative week and subjective responses to pulp sensibility tests at 12 months follow-up. Method 120 patients presenting with necrotic pulp and periapical lesions will be randomly allotted to one of the three groups - REP using i-PRF or BC or RCT group. Comparative evaluation of outcome of REP and RCT will be performed at 12-months follow-up.

Details

Lead sponsor	Postgraduate Institute of Dental Sciences Rohtak
Phase	NA
Status	UNKNOWN
Enrolment	40
Start date	Mon May 01 2023 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Sun Sep 01 2024 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Apical Periodontitis

Interventions

• Root canal treatment
• Regenerative endodontic procedure

Countries

India