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NCT06179290
Changes in Biomarker of Exposure in Adults Who Smoke Cigarettes Switching From Cigarettes to Heated Tobacco Products
NA trial testing Ploom HTP Menthol HTS; MX3 (681) in Tobacco Use in 921 participants. Completed in 24 March 2025.
15 May 2024
Quick facts
| Lead sponsor | Altria Client Services LLC |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | other |
| Enrollment | 921 |
| Start date | 2 October 2023 |
| Primary completion | 15 May 2024 |
| Estimated completion | 24 March 2025 |
| Sites | 7 locations across United States |
Drugs / interventions tested
- Ploom HTP Menthol HTS; MX3 (681)
- Ploom HTP Tobacco HTS; R8 (120)
- Smoking Abstinence (menthol)
- Smoking Abstinence (non-menthol)
Conditions studied
- Tobacco Use — all drugs for Tobacco Use →
Sponsor
Altria Client Services LLC — full company profile →
Who can join
Adults 22 to 65, any sex, with Tobacco Use. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of the study is to evaluate changes in biomarkers of exposure (BoE) to harmful and potentially harmful constituents (HPHCs) in adult smokers who completely switch to Ploom heated tobacco products (HTPs) compared to those who continue to smoke usual brand combustible cigarettes (UBCC).
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06179290
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Tobacco Use
Currently open trials in the same condition.
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- NCT07132814 — Abuse Liability for Five Modern Oral Nicotine Products · NA · recruiting
- NCT07148232 — Extended Intervention for Tobacco Use (EXIT) for People Experiencing Homelessness · Phase 4 · recruiting
- NCT06983678 — Neural Correlates and Behavioral Impact of Withdrawal-induced Hyperalgesia Among People Who Smoke With and Without Chron · NA · recruiting
- NCT06922617 — STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking · NA · recruiting
Other Altria Client Services LLC trials
Trials by the same sponsor.
- NCT06476405 — Room Air Levels of Harmful and Potentially Harmful Constituents After Heated Tobacco Product Use and Cigarettes · completed
- NCT06356610 — Pharmacokinetic and Subjective Effects of Heated Tobacco Products · NA · completed
- NCT06691386 — Nicotine Pharmacokinetics and Subjective Effects of Oral Nicotine Products Relative to Smokeless Tobacco in Adult Users · NA · completed
- NCT05664672 — Study to Evaluate Changes in Smokers Using on!® Nicotine Pouches · NA · completed
- NCT03692078 — A Study to Evaluate Changes in Smokers Using Oral Tobacco-derived Nicotine Products. · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06179290 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Altria Client Services LLC
- Last refreshed: 4 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06179290.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing