Efficacy of Manuka Honey Nano-Formulatin on the Clinical Improvement and Inflammatory Markers Reduction in Patients With Acne Vulgaris

NCT06175819 NA UNKNOWN

The present study aims to manufacture manuka honey-loaded nano-formulation using natural materials as a potent tissue-healing remedy and compare it to commercially available antimicrobial therapy in order to reduce the severity and recurrences of skin lesions.

Details

Lead sponsor	Al-Azhar University
Phase	NA
Status	UNKNOWN
Enrolment	102
Start date	2024-01
Completion	2024-09-11

Conditions

• Acne Vulgaris

Interventions

• Manuka honey( MgO 850, UMF+20) loaded nano-formulation

Primary outcomes

• Clinical evaluation — 4 weeks
  Clinical evaluation: (Yun Chen MM et al.,2023) * cure :Reduction of lesion area ≥90% * Significant effect: The lesion area was reduced by 60%-89% * Effective: Skin lesion area reduced by 30%-59% * Invalid: Reduction of lesion area ≤29% * cure :Reduction of lesion area ≥90% * Significant effect: The lesion area was reduced by 60%-89% * Effective: Skin lesion area reduced by 30%-59% * Invalid: Reduction of lesion area ≤29%
• Acne severity evaluation — 4 weeks
  Acne severity evaluation : The skin lesion scores were calculated before treatment and 4 weeks after treatment according to Global acne grading system (GAGS). (Yun Chen MM et al.,2023).