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Spinal Cord Associative Plasticity for ALS
Veterans are at higher risk than non-Veterans of falling ill with amyotrophic lateral sclerosis (ALS). The investigators have shown that synchronized stimulation over the brain and cervical spinal cord can temporarily strengthen weakened nerve circuits between the brain and hand muscles in people with ALS. The current proposal will take the next step of individualizing this intervention, then applying it repetitively in an attempt to achieve direct clinical benefit on hand strength and function. Following an initial 2-3 month period of optimizing the intervention for each individual, the investigators will compare the effects of two-week programs of paired brain-spinal stimulation with or without hand exercises.
Details
| Lead sponsor | VA Office of Research and Development |
|---|---|
| Phase | NA |
| Status | RECRUITING |
| Enrolment | 32 |
| Start date | Mon Apr 01 2024 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Tue Feb 29 2028 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Amyotrophic Lateral Sclerosis
Interventions
- Spinal Cord Associative Plasticity (SCAP)
- Upper extremity task-oriented exercise
Countries
United States