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NCT06171594
The Effect of Chlorhexidine on the Oral Microbiome and Saliva in Dental Erosion
NA trial testing Chlorhexidine mouthwash in Dental Erosion in 24 participants. Status unknown.
30 July 2024
Quick facts
| Lead sponsor | University of Portsmouth |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | triple |
| Primary purpose | diagnostic |
| Enrollment | 24 |
| Start date | 20 December 2023 |
| Primary completion | 30 July 2024 |
| Estimated completion | 20 December 2024 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Chlorhexidine mouthwash — full drug profile →
Conditions studied
- Dental Erosion — all drugs for Dental Erosion →
Sponsor
University of Portsmouth
Who can join
Adults 18 to 75, any sex, with Dental Erosion. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Dental erosion happens when the teeth lose some of their parts because of acid from the things people eat and/or drink or even from stomach. It can make teeth hurt and become sensitive. The mouth has a protective shield called salivary pellicle that helps, and there are some special bacteria called Nitrate-reducing bacteria (NRB) that can be good for the mouth and heart. Eating some fruits and vegetables or drinking beetroot can make these bacteria thrive, which might help the heart and blood pressure. This study wants to see how administering chlorhexidine mouthwash affects the good bacteria in the mouth for people with healthy teeth and those with erosion. This study aims to find out if this mouthwash can change the saliva and bacteria in the mouth for the better, in people with both healthy teeth and those with dental erosion. The proposed study is part of a PhD educational project and will be a double blind, randomised design, crossover trial for the effect of Chlorhexidine (CHX) mouthwash on healthy control and people with dental erosion (PwDE). This study aims to explore mouthwash's effect on oral microbiome recovery in WMS and salivary pellicle and its impact on blood pressure and arterial stiffness in healthy controls PwDE
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06171594
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Related trials
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Trials testing the same drug.
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- NCT06021847 — Ozonated Water in Treatment of Denture Stomatitis · NA · completed
- NCT05787600 — Anti-inflammatory and Anti-plaque Efficacies of Mouth Rinse Containing Hyaluronic Acid and Hydrogen Peroxide · Phase 3 · completed
Other University of Portsmouth trials
Trials by the same sponsor.
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- NCT05896488 — Sweat Response, Sweat Composition and Thermoregulatory Response to Exercise in Heat in Adults With Cystic Fibrosis on Mo · unknown
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06171594 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Portsmouth
- Last refreshed: 14 December 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06171594.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing