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NCT06170463
Insulin Sensitizers Role in Control of PCOS Vicious Cycle.
Phase 1 trial testing Metformin Hydrochloride in PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries in 210 participants. Completed in 15 April 2023.
1 March 2023
Quick facts
| Lead sponsor | Zagazig University |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 210 |
| Start date | 1 August 2022 |
| Primary completion | 1 March 2023 |
| Estimated completion | 15 April 2023 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Metformin Hydrochloride — full drug profile →
- MI/DCI combination in 40:1 ratio — full drug profile →
- Combination of Metformin hydrochloride and MI/DCI — full drug profile →
Conditions studied
- PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries — all drugs for PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries →
Sponsor
Zagazig University
Who can join
Adults 18 to 45, female only, with PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
PCOS is a common and complex disease affecting women of reproductive age. It is characterized by its complex pathological symptoms and mechanisms resulting in endocrine and metabolic dysfunction. PCOS is highly associated with various metabolic and endocrinal disorders. Metformin is mainly used for its glucose-lowering effects for treatment and prevention of type-2 diabetes mellitus (DM), gestational DM, and PCOS. Myo-inositol (MI) protects against MAFLD through reduction of hepatic accumulation of triglycerides.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06170463
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Metformin Hydrochloride
Trials testing the same drug.
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- NCT06920056 — A Study of BGM0504 in Overweight or Obese Participants · Phase 1 · completed
- NCT06638671 — Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity · Phase 4 · recruiting
- NCT05828303 — A Phase 1 Study to Evaluate the Potential Drug Interactions Between Repotrectinib and Metformin, Digoxin, and Rosuvastat · Phase 1 · withdrawn
Other recruiting trials for PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries
Currently open trials in the same condition.
- NCT07182526 — Effects of Adding Quercetin or Alpha Lipoic Acid to Usual Care on Symptoms and Blood Markers in Iraqi Women With Polycys · Phase 2 · recruiting
- NCT05734287 — The Frequency of Polycystic Ovary Syndrome Among Young Reproductive Females Presenting With Hyperandrogenism: a Mixed Co · recruiting
- NCT06050265 — Glucose Evaluation Through Continuous Glucose Monitors in Polycystic Ovary Syndrome · NA · active not recruiting
- NCT05819853 — Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome · Phase 3 · recruiting
- NCT05756023 — IVF\ICSI Outcome in Women With Polycystic Ovary Syndrome · NA · recruiting
Other Zagazig University trials
Trials by the same sponsor.
- NCT07423676 — Comparison Between Two Drugs in Sedation of Upper GI Endoscopy · not yet recruiting
- NCT07418307 — Comparison Between Combined Biceps Femoris Short Head Block and Adductor Canal Block Versus Genicular Nerve Block · NA · not yet recruiting
- NCT07435025 — Surgery for Obstructed Gastric Carcinoma · NA · active not recruiting
- NCT07330375 — Effect of Intravenous Dexmedetomidine and Ketamine on Post-Operative Analgesia · Phase 3 · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06170463 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Zagazig University
- Last refreshed: 20 December 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06170463.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing