NCT06161805 (EASYlight) is a Phase 3 clinical trial of Esketamine hydrochloride in Endometriosis, sponsored by Reinier de Graaf Groep.

Who is sponsoring NCT06161805?

NCT06161805 is sponsored by Reinier de Graaf Groep.

What drugs are being tested in NCT06161805?

Interventions in NCT06161805: Esketamine hydrochloride, Placebo.

What condition does NCT06161805 study?

NCT06161805 studies Endometriosis, Chronic Pelvic Pain Syndrome.

Is NCT06161805 still recruiting?

NCT06161805 is currently recruiting now. Last updated 11 April 2025.

Last reviewed 2025-04-11 · How we verify

NCT06161805: EASYlight

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Esketamine as Treatment for Chronic Pain Due to Endometriosis: a RCT Study

Recruiting now Phase 3 Last updated 11 April 2025

What this trial tests

Phase 3 trial testing Esketamine hydrochloride in Endometriosis in 56 participants. Currently enrolling.

Timeline

1 March 2024

Primary endpoint
1 January 2026

1 June 2026

Quick facts

Lead sponsor	Reinier de Graaf Groep
Phase	Phase 3
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	56
Start date	1 March 2024
Primary completion	1 January 2026
Estimated completion	1 June 2026
Sites	1 location across Netherlands

Drugs / interventions tested

Esketamine hydrochloride — full drug profile →
Placebo

Conditions studied

Endometriosis — all drugs for Endometriosis →
Chronic Pelvic Pain Syndrome — all drugs for Chronic Pelvic Pain Syndrome →

Sponsor

Reinier de Graaf Groep — full company profile →

Who can join

Adults 18 to 50, female only, with Endometriosis or Chronic Pelvic Pain Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this randomized controlled trial is to investigate the effect of esketamine versus placebo on the NRS score for chronic pelvic pain. Secondary endpoints are to assess pain scores, side-effects, quality of life, depressive symptoms and pain coping.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other trials of Esketamine hydrochloride

Trials testing the same drug.

NCT07063108 — Efficacy and Safety of S-ketamine in Elderly Patients Undergoing Non-cardiac Surgery: a RCT（ESSENCE） · Phase 4 · not yet recruiting
NCT05603104 — Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First- · Phase 3 · recruiting
NCT06579937 — Effects of Esketamine on Postoperative Behavioral Changes in Children Undergoing Tonsillectomy and/or Adenoidectomy · Phase 4 · recruiting
NCT05973851 — The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Us · Phase 3 · recruiting
NCT06199011 — Effect of Esketamine on Depressive Symptoms of Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy · NA · unknown

Other recruiting trials for Endometriosis

Currently open trials in the same condition.

NCT06559852 — The Impact of Yoga on Endometriosis-Related Pain · NA · recruiting
NCT07393295 — Efficacy and Tolerability of TENS in Endometriosis-related Pain · NA · recruiting
NCT07134023 — Educational Program for the Multidisciplinary Support of Patients With Endometriosis · NA · recruiting
NCT07240883 — ENDO1000 - A UK-wide Endometriosis Research Project · recruiting
NCT06974773 — Remote Electrical Stimulation as a Long-term Intervention for Endometriosis Flare Ups · NA · recruiting

Other Reinier de Graaf Groep trials

Trials by the same sponsor.

NCT07077174 — Effects of PERMISSive Lung-protective Ventilation on Outcome in Critically Ill Invasively Ventilated Patients · NA · recruiting
NCT06106529 — REDucing Hot FLASHes in Women Using Endocrine Therapy. · Phase 3 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06161805 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Reinier de Graaf Groep
Last refreshed: 11 April 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06161805.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing