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NCT06160739
Role of Sirolimus in Treatment of Microcystic , Mixed Lymphatic and Vascular Malformations
trial testing Sirolimus 1Mg Oral Tablet in Microcystic Lymphatic Malformation in 10 participants. Status unknown.
1 September 2024
Quick facts
| Lead sponsor | Sohag University |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 10 |
| Start date | 20 November 2023 |
| Primary completion | 1 September 2024 |
| Estimated completion | 1 September 2024 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Sirolimus 1Mg Oral Tablet — full drug profile →
Conditions studied
- Microcystic Lymphatic Malformation — all drugs for Microcystic Lymphatic Malformation →
- Combined Vascular Malformation — all drugs for Combined Vascular Malformation →
- Vascular Malformations — all drugs for Vascular Malformations →
Sponsor
Sohag University
Who can join
Adults 6 Months to 12, any sex, with Microcystic Lymphatic Malformation or Combined Vascular Malformation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Lympho-vascular malformations result from errors in embryologic vasculogenesis involving capillaries, veins, arteries, lymphatics, or a combination of these. Infantile haemangiomas \& Vascular malformations like : Capillary malformations \& Venous malformations : they increase in size and never regress on their own. \& They are generally present at birth, they enlarge in response to infection, hormonal changes or trauma . Lymphatic malformations can be classified into macrocystic (cyst diameter \>1cm), microcystic (cyst diameter \<1 cm), or mixed , in macrocystic lymphatic malformations, surgery and sclerotherapy are effective . Surgery of microcystic lymphatic malformations remains challenging due to their infiltrative nature \& Sclerotherapy is often impossible. As especially large microcystic and mixed malformations are still a therapeutic challenge, pharmaceutical treatment as sirolimus is used in last years as main line of treatment with great efficacy.
Publications & conference data
4 peer-reviewed publications reference this trial (live from Europe PMC):
-
A Review of the Current State and Future Directions for Management of Scalp and Facial Vascular Malformations.
Hartman E, Balkin DM, See AP. · · 2024 · cited 3× · PMID 38720545 · DOI 10.3340/jkns.2024.0032 -
PI3K/AKT/mTOR axis in vascular malformations: from molecular insights to targeted clinical trials.
Zheng YY, Hua C, Lin XX. · · 2025 · cited 1× · PMID 41430313 · DOI 10.1186/s13023-025-04115-2 -
Targeted medical therapies for vascular anomalies.
Borst A. · · 2024 · cited 1× · PMID 39644074 · DOI 10.1182/hematology.2024000599 -
Vascular malformations: from genetics to therapeutics.
Morin G, Galasso I, Canaud G. · · 2026 · PMID 41272322 · DOI 10.1038/s44321-025-00344-x
Verify or expand the search:
- PubMed search for NCT06160739
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06160739 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Sohag University
- Last refreshed: 15 December 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06160739.
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