Last reviewed · How we verify
NCT06152068: CIMT
Insulin Resistance, Lipid Profile, CRP, IL-18 and Carotid Intima-Media Thickness (CIMT) Diameter in Obese Adolescents
trial in Obesity, Adolescent in 50 participants. Completed in 30 April 2024.
31 March 2024
Quick facts
| Lead sponsor | Universitas Airlangga |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 50 |
| Start date | 1 October 2023 |
| Primary completion | 31 March 2024 |
| Estimated completion | 30 April 2024 |
| Sites | 1 location across Indonesia |
Conditions studied
- Obesity, Adolescent — all drugs for Obesity, Adolescent →
Sponsor
Universitas Airlangga — full company profile →
Who can join
Adults 13 to 18, any sex, with Obesity, Adolescent. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Carotid intima-media thickness (CIMT) is a marker for detecting endothelium dysfunction, and has become a non-invasive method that is very useful in detecting and evaluating subclinical atherosclerosis in obese children and adolescents. This method is very useful in visually detecting and monitoring changes in the intima and its medial thickness, and can also evaluate changes within the arterial wall in the absence of localized plaque. Previous research that was conducted found an increase in CIMT diameter in 44 of 59 obese adolescents. Obesity has a risk of increasing the diameter of CIMT which carries the risk of atherosclerosis. Obesity accompanied by insulin resistance, and metabolic syndrome has a greater risk of atherosclerosis. Currently, the prevalence of obesity in adolescents is increasing. Interleukin 18 is a group of interleukin 1 whose levels increase in chronic inflammatory processes such as obesity, metabolic syndrome, and type 2 diabetes mellitus. IL-18 levels increase in obesity with increased CIMT. Assessment of cardiovascular risk in obese adolescents is still a challenge for health practitioners, to prevent cardiovascular complications in obese adolescents which can cause sudden death at a young age. It is necessary to assess changes in the cardiovascular system that can be identified early by knowing the CIMT diameter. However, there is no definite reference value so the CIMT can be used as a reference for the occurrence of subclinical atherosclerosis in obese adolescents. In the previous study, CIMT was not examined in non-obese adolescents, so the cut-off for CIMT in non-obese was not known. Therefore, we have the opportunity to research to determine the thickness of CIMT and determine the cut-off value of CIMT which is at risk of experiencing early atherosclerosis in the obese adolescent population.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06152068
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Obesity, Adolescent
Currently open trials in the same condition.
- NCT06920862 — Multi-Modal Digital Interventions for Adolescent Weight Management · NA · recruiting
- NCT06822387 — Health Without Barriers/Salud Sin Barreras- Northern Colorado · NA · recruiting
- NCT06309121 — Effects of the Postbiotic Blend ABB C3 on Adiposity and Glucose Metabolism in Children and Adolescents · NA · active not recruiting
- NCT05982847 — National Blood Pressure Screening in Children to Improve Paediatric Healthcare in South Africa · recruiting
- NCT06515288 — Nutrition Goes to School: a School-based Nutrition Intervention to Promote Healthy Eating Behaviour Among Adolescents · NA · recruiting
Other Universitas Airlangga trials
Trials by the same sponsor.
- NCT07418762 — Community-Based Program Integrating Nurse-Led Mind-Body Exercise and Nutrition for Frailty · NA · not yet recruiting
- NCT07265856 — The Effect of a Comprehensive Dementia Education Program on Improving Attitudes Toward People Living With Dementia · NA · enrolling by invitation
- NCT07238439 — Scenario-Driven Virtual Reality Game for Dementia Education Program · NA · enrolling by invitation
- NCT06629844 — Enhancing Healthcare Students' Attitudes Toward Dementia Care Through Virtual Reality Education · NA · completed
- NCT06160765 — The Efficacy of High Density Formula 1.5 kcal/ml or 1 kcal/ml On Catch Up Growth In Growth Faltering Children · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06152068 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Universitas Airlangga
- Last refreshed: 3 June 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06152068.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing