Last reviewed · How we verify
NCT06148077: MaTeO
Manual Therapy on Oral Opening, Swallow Function and Upper Quarter Mobility on Head and Neck Cancer Survivors
NA trial testing Manual Therapy in Head and Neck Cancer in 70 participants. Currently enrolling.
1 October 2025
Quick facts
| Lead sponsor | Universidad de La Frontera |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 70 |
| Start date | 25 September 2024 |
| Primary completion | 1 October 2025 |
| Estimated completion | 1 October 2025 |
| Sites | 2 locations across Chile |
Drugs / interventions tested
- Manual Therapy
- Motor control exercises
Conditions studied
- Head and Neck Cancer — all drugs for Head and Neck Cancer →
- Trismus — all drugs for Trismus →
- Dysfunction — all drugs for Dysfunction →
Sponsor
Universidad de La Frontera — full company profile →
Who can join
18 and older, any sex, with Head and Neck Cancer or Trismus. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Trismus has been reported as the second most common comorbidity in survivors of head and neck cancer (HNC). It is mainly associated with post-radiotherapy subcutaneous fibrosis, muscular atrophy, damage to neurological structures in the neck, or a combination of all, affecting masticatory musculature. In addition to this, the loss of flexibility and strength in the shoulder has also been shown to be related to deficits in the function and quality of life of these patients. The goal of this clinical trial is to determinate the effectiveness and safety of Manual Therapy (MT) on Oral Opening, Swallow Function, as well as the mobility of the upper quarter, the strength of cervical musculature, pain, functionality, and the perception of quality of life in head and neck cancer survivors. Participants will be assigned randomly to the study groups: a) manual therapy program and control motor exercises and b) motor control exercises (usual care). The assessment refers to a baseline form (at the beginning of the study), at 6 weeks and at 6 weeks of patient follow-up.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effects of manual therapy on oral opening, swallow function and upper quarter mobility in Chilean survivors of head and neck cancer: a study protocol for a controlled, randomised study (MAnual ThErapy for Oral Opening (MATEO) study).
Burgos-Mansilla B, Schneeberger-Hitschfeld P, Astete-Barra K, Méndez-Rojas A, et al · · 2025 · PMID 40897487 · DOI 10.1136/bmjopen-2024-097131
Verify or expand the search:
- PubMed search for NCT06148077
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Head and Neck Cancer
Currently open trials in the same condition.
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Other Universidad de La Frontera trials
Trials by the same sponsor.
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- NCT06974071 — Effectiveness of Nonpharmacologic Therapies on Pain After Removal of Chest Drains in Postoperative Cardiac Surgery · NA · active not recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06148077 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Universidad de La Frontera
- Last refreshed: 30 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06148077.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing