NCT06147284: jcpdmcP

MOVIN' CARE for PD (Risk Management)

Active, enrolled NA Last updated 11 December 2023

What this trial tests

NA trial testing Preventive interventions in Parkinson's Disease (At-risk Cases) in 308 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

26 July 2023

Primary endpoint
31 January 2027

11 June 2027

Quick facts

Lead sponsor	The University of Hong Kong
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	308
Start date	26 July 2023
Primary completion	31 January 2027
Estimated completion	11 June 2027
Sites	1 location across Hong Kong

Drugs / interventions tested

• Preventive interventions

Conditions studied

• Parkinson's Disease (At-risk Cases) — all drugs for Parkinson's Disease (At-risk Cases) →

Sponsor

The University of Hong Kong

Who can join

18 and older, any sex, with Parkinson's Disease (At-risk Cases). Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this intervention study is to investigate the effectiveness of three preventive interventions - yoga, arts-based approaches, and somatic practices, with reference to an active control group - traditional exercises, in enhancing psycho-social-spiritual well-being among people at risk of Parkinson's disease (Parkivers). The hypotheses include:

H1: Yoga, arts-based, somatic interventions will significantly improve the psycho-social- spiritual wellbeing (i.e., perceived stress, anxiety and depressive symptoms, and quality of life) among Parkivers H2: In comparison to traditional exercise, yoga, arts-based, and somatic interventions will have a significant effect on psycho-social-spiritual well-being among Parkivers H3: Yoga, arts-based, somatic, and traditional exercise training interventions will have a significant effect in reducing PD-related motor symptoms H4: Yoga, arts-based, somatic interventions have a significant long-term effect on improving psycho-social-spiritual well-being among Parkivers

Eligible participants will be invited to undergo baseline assessments before randomization to attend a six-session intervention group. To investigate the immediate and long-term effect of the preventive measures, repeated outcome measures will be conducted at six time-points: A baseline assessment prior to randomization (T0), and follow-ups at 2-months (T1), 6-months (T2), 12-months (T3), 18- months (T4), 24-months (T5).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. From the Gut to the Brain: Is Microbiota a New Paradigm in Parkinson's Disease Treatment?
   Vilela C, Araújo B, Soares-Guedes C, Caridade-Silva R, et al · · 2024 · cited 7× · PMID 38727306 · DOI 10.3390/cells13090770