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NCT06143488
Endovascular Therapy Versus Best Medical Treatment for Acute Large Vessel Occlusion Stroke With Low NIHSS
NA trial testing Endovascular therapy in Acute Ischemic Stroke in 264 participants. Currently enrolling.
30 June 2025
Quick facts
| Lead sponsor | First Affiliated Hospital of Wannan Medical College |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 264 |
| Start date | 7 February 2024 |
| Primary completion | 30 June 2025 |
| Estimated completion | 31 March 2028 |
| Sites | 1 location across China |
Drugs / interventions tested
- Endovascular therapy
- Best medical management — full drug profile →
Conditions studied
- Acute Ischemic Stroke — all drugs for Acute Ischemic Stroke →
- Mild Neurocognitive Disorder — all drugs for Mild Neurocognitive Disorder →
- Thrombectomy — all drugs for Thrombectomy →
Sponsor
First Affiliated Hospital of Wannan Medical College
Who can join
18 and older, any sex, with Acute Ischemic Stroke or Mild Neurocognitive Disorder. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Patients presenting with mild symptoms of acute ischemic stroke are common and account for approximately half of all acute ischemic stroke. About 30% of patients with minor stroke have a 90-day functional disability. Radiologically proven a large vessel occlusion (LVO) in patients with minor stroke is a well-established predictor of poor outcomes, while the poor outcomes following best medical management in patients with minor stroke with the underlying presence of a LVO are mainly driven by the occurrence of early neurological deterioration (END). Considering the well-known strong association between lack of arterial recanalization and END, endovascular therapy (EVT) appears as an attractive option to improve functional outcomes for LVO-related patients with stroke with mild symptoms. Whether EVT is safe and effective in patients with mild stroke with an LVO is currently debated, since these patients were typically excluded from the pivotal EVT trials. The current study aimed to further test the hypothesis that endovascular therapy would be superior to medical management with respect to functional recovery among low NIHSS patients caused by acute large-vessel occlusion in the anterior circulation.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06143488
- Europe PMC full search
- ASCO Meeting Library
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Currently open trials in the same condition.
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Other First Affiliated Hospital of Wannan Medical College trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06143488 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by First Affiliated Hospital of Wannan Medical College
- Last refreshed: 8 January 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06143488.
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