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Radiotherapy in Combination With TTI-101 in Borderline Resectable and Locally Advanced Pancreatic Ductal Adenocarcinoma
The survival rate for patients with pancreatic cancer remains at a dismal 10% or less at 5 years, and although trials integrating stereotactic body radiation therapy (SBRT) alone have shown improvement in local control, initial invigoration of immune response, and relief of symptom burden, SBRT has not demonstrated any improvement in survival. Preclinical research has established that STAT3 inhibition given concurrently with SBRT and in the maintenance phase acts as a synergistic agent that enhances the pro-inflammatory effects of SBRT while reducing its undesired effects (including fibrosis and immunosuppression). This study exploits the window of opportunity post-chemotherapy to advance the hypothesis that the addition of STAT3 inhibition in combination with SBRT will be safe and will enhance 2-year progression-free survival.
Details
| Lead sponsor | Washington University School of Medicine |
|---|---|
| Phase | PHASE1 |
| Status | ACTIVE_NOT_RECRUITING |
| Enrolment | 5 |
| Start date | Tue Jan 16 2024 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Sat Jun 30 2029 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Pancreatic Cancer
Interventions
- TTI-101
- Stereotactic body radiation therapy
Countries
United States