Last reviewed · How we verify
NCT06138223: RADICES
The Effect of exeRcise And Diet on Quality of Life in Patients With Incurable Cancer of Esophagus and Stomach (RADICES)
NA trial testing Exercise intervention in GastroEsophageal Cancer in 196 participants. Currently enrolling.
30 September 2028
Quick facts
| Lead sponsor | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | supportive care |
| Enrollment | 196 |
| Start date | 1 January 2024 |
| Primary completion | 30 September 2028 |
| Estimated completion | 30 September 2028 |
| Sites | 12 locations across Netherlands |
Drugs / interventions tested
- Exercise intervention
- Nutrition intervention
Conditions studied
- GastroEsophageal Cancer — all drugs for GastroEsophageal Cancer →
- Incurable Disease — all drugs for Incurable Disease →
Sponsor
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) — full company profile →
Who can join
18 and older, any sex, with GastroEsophageal Cancer or Incurable Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The survival of patients with incurable gastroesophageal cancer can extend over a year with anticancer therapy. However, the number of patients with deteriorating quality of life in this patient group steadily decreases over time during the treatment. Potentially reversible causes related to deterioration of quality of life are diminished muscle mass, physical capacity and nutritional status. Therefore, interventions that can target these in order to maintain or improve quality of life are urgently needed. However, it is yet unknown whether improvement of physical capacity and nutritional status improves quality of life in patients with incurable gastroesophageal adenocarcinoma after failure of first-line treatment. Since these patients are in a precarious situation, the benefits and harms of a combined exercise and nutritional intervention should be carefully evaluated.Therefore this study investigates the effect of a combined exercise and nutrition intervention compared to usual care on quality of life in incurable GAC patients after progression upon first-line treatment. A total of 196 patients with metastasized gastroesophageal cancer will be recruited and randomly allocated 1:1 to standard care or standard care plus a combined exercise and nutritional intervention.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Multicomponent Interventions for Adults With Cancer Cachexia: A Systematic Review.
Bowers M, Petrasso C, McLuskie A, Bayly J, et al · · 2025 · cited 6× · PMID 40012451 · DOI 10.1002/jcsm.13716 -
Effects of exercise and diet in patients with incurable gastroesophageal cancer: the RADICES study.
Bonhof A, Hiensch AE, Wierdsma NJ, Huis In 't Veld LF, et al · · 2026 · cited 1× · PMID 41592243 · DOI 10.1093/jncics/pkag006
Verify or expand the search:
- PubMed search for NCT06138223
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Exercise intervention
Trials testing the same drug.
- NCT07059884 — Distance-Based Exercise to Preserve Function and Prevent Disability · NA · recruiting
- NCT07271082 — Efficacy and Safety of Home-based Structured Physical Exercise in Patients With Acute Ischemic Stroke · NA · recruiting
- NCT06962579 — The Effect of Personalized Exercise Interventions for the Prevention of Chemotherapy-induced Peripheral Neuropathy · NA · recruiting
- NCT06785324 — Study of Nutrition and Exercise in Adults Hospitalized for Treatment of Acute Lymphoblastic Leukemia (ALL) · NA · recruiting
- NCT06931210 — Study of AI-based Prediction Models for Exercise-Induced Gut Microbiota Alterations in Patients With Type 2 Diabetes · NA · completed
Other recruiting trials for GastroEsophageal Cancer
Currently open trials in the same condition.
- NCT06906887 — PULSO Trial: Pulsed Low-Dose-Rate (PLDR) Radiation Chemoradiation (CRT) vs. Standard CRT for Esophageal Cancer · Phase 2 · recruiting
- NCT06028737 — Total Neoadjuvant FLOT Chemotherapy in Locally Advanced Gastric and Gastroesophageal Junction Cancer · Phase 2, PHASE3 · recruiting
- NCT06422403 — A Value-Driven Study on Reducing Immune Checkpoint Inhibitor Dosing Frequency in Advanced Cancers · Phase 2 · recruiting
- NCT06243757 — A Study of Minimally Invasive Proximal Gastrectomy Versus Minimally Invasive Total Gastrectomy for Gastric and Gastroeso · active not recruiting
- NCT05644431 — GastrOesophageal Tumor, Immune Microenvionnment (GOTIM) · recruiting
Other Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) trials
Trials by the same sponsor.
- NCT07301021 — Velopharyngeal Insufficiency After Maxillomandibular Advancement Osteotomy in Obstructive Sleep Apnea Patients · not yet recruiting
- NCT07359482 — sElective Serotonin reuPtake inhibitoRs In posT-covid After COVID-19 · Phase 3 · not yet recruiting
- NCT07457957 — Effectiveness of an mHealth Innovation on the Impact of Menstrual Complaints in Adolescents · NA · not yet recruiting
- NCT06909045 — Adaptive vs. Continuous Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease · NA · recruiting
- NCT07316127 — Immunoadsorption in Autoimmune Long COVID · Phase 2 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06138223 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
- Last refreshed: 22 July 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06138223.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing