NCT06135051 is a Phase 1, PHASE2 clinical trial of Diadem prototype in Alzheimer Disease, sponsored by University of Utah.

Who is sponsoring NCT06135051?

NCT06135051 is sponsored by University of Utah.

What drugs are being tested in NCT06135051?

Interventions in NCT06135051: Diadem prototype.

What condition does NCT06135051 study?

NCT06135051 studies Alzheimer Disease, Dementia, Cognitive Impairment.

Is NCT06135051 still recruiting?

NCT06135051 is currently terminated. Last updated 25 May 2025.

Last reviewed 2025-05-25 · How we verify

NCT06135051

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Ultrasonic Neuromodulation for Treatment of Cognitive Impairment

Terminated Phase 1, PHASE2 Last updated 25 May 2025

What this trial tests

Phase 1, PHASE2 trial testing Diadem prototype in Alzheimer Disease in 1 participant. Terminated before completion.

Timeline

18 August 2024

Primary endpoint
21 August 2024

21 August 2024

Quick facts

Lead sponsor	University of Utah
Phase	Phase 1, PHASE2
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	triple
Primary purpose	treatment
Enrollment	1
Start date	18 August 2024
Primary completion	21 August 2024
Estimated completion	21 August 2024
Sites	1 location across United States

Drugs / interventions tested

Diadem prototype

Conditions studied

Alzheimer Disease — all drugs for Alzheimer Disease →
Dementia — all drugs for Dementia →
Cognitive Impairment — all drugs for Cognitive Impairment →

Sponsor

University of Utah

Who can join

Adults 18 to 80, any sex, with Alzheimer Disease or Dementia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will evaluate a new form of non-invasive deep brain therapy for individuals with Alzheimer's disease. Low-intensity transcranial focused ultrasound stimulation will first be delivered using a range of stimulation parameters during psychophysical and physiological monitoring. A well-tolerated stimulation protocol will be selected for subsequent testing in a blinded randomized sham-controlled cross-over trial. The trial will evaluate brain target engagement using magnetic resonance imaging, PET imaging, and numerical scales of cognitive performance.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Current state of clinical ultrasound neuromodulation.
Matt E, Radjenovic S, Mitterwallner M, Beisteiner R. · · 2024 · cited 27× · PMID 38962179 · DOI 10.3389/fnins.2024.1420255
Low-intensity transcranial ultrasound neuromodulation promotes neuronal regeneration: A new hope for noninvasive treatment of neurodegenerative diseases.
Xia S, He C, Li Y, Li H, et al · · 2026 · cited 1× · PMID 40817729 · DOI 10.4103/nrr.nrr-d-25-00113

Verify or expand the search:

Other trials of Diadem prototype

Trials testing the same drug.

NCT05301036 — Personalized Ultrasonic Brain Stimulation for Depression · Phase 1, PHASE2 · active not recruiting

Other recruiting trials for Alzheimer Disease

Currently open trials in the same condition.

NCT07290387 — Tele-Savvy for Latino Caregivers · NA · recruiting
NCT07178210 — Robotic-Enabled Microsurgical Intervention for Neurodegenerative Disease · NA · recruiting
NCT07294885 — Deep Cervical LymphatIc-Venous Anastomosis for Alzheimer's Disease · NA · recruiting
NCT06937229 — A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3) · Phase 3 · recruiting
NCT06930560 — HEARS-NPS: Addressing Hearing Loss as a Common Unmet Contributor of Neuropsychiatric Symptoms · NA · recruiting

Other University of Utah trials

Trials by the same sponsor.

NCT07515755 — Supplemental Oxygen and Oxygen Desaturations in Colonoscopies · NA · not yet recruiting
NCT07225426 — Personalizing Financial Incentives · NA · recruiting
NCT06716411 — Confirming the Effects of Acupuncture Treatments to Relieve Symptoms of Gulf War Illness · NA · recruiting
NCT07246538 — Positive Airway Pressure (PAP) System Evaluation in Volunteers · NA · not yet recruiting
NCT04208984 — Diversion Device With Breath Control · withdrawn

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06135051 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Utah
Last refreshed: 25 May 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06135051.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing