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NCT06131580: ISS-CA-2023
Canadian Continuation of Roll-over Study in Patients With Endogenous Cushing's Syndrome
Phase 4 trial testing Intervention/Treatment in Endogenous Cushing Syndrome in 7 participants. Status unknown.
24 November 2025
Quick facts
| Lead sponsor | Centre hospitalier de l'Université de Montréal (CHUM) |
|---|---|
| Phase | Phase 4 |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 7 |
| Start date | 24 October 2023 |
| Primary completion | 24 November 2025 |
| Estimated completion | 24 November 2025 |
| Sites | 3 locations across Canada |
Drugs / interventions tested
- Intervention/Treatment — full drug profile →
Conditions studied
- Endogenous Cushing Syndrome — all drugs for Endogenous Cushing Syndrome →
Sponsor
Centre hospitalier de l'Université de Montréal (CHUM)
Who can join
Adults 18 to 75, any sex, with Endogenous Cushing Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to continue the evaluation of long-term safety of osilodrostat in 7 Canadian patients who have already received osilodrostat treatment in a previous Global Recordati-sponsored roll-over study and who, based on investigators' judgement, will continue benefiting with its administration.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
Verify or expand the search:
- PubMed search for NCT06131580
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Intervention/Treatment
Trials testing the same drug.
- NCT06179875 — An Open-label Study (OLE) for Non-responders of VRDN-001-101 and VRDN-001-301 · Phase 3 · completed
Other Centre hospitalier de l'Université de Montréal (CHUM) trials
Trials by the same sponsor.
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- NCT05225272 — Effectiveness of an Enhanced Recovery After Surgery Protocol in Patients Undergoing On-pump Cardiac Surgery · not yet recruiting
- NCT07497061 — Comparison of Two Surgical Techniques for the Treatment of Trigger Fingers: Longitudinal Opening Versus Complete A1 Pull · NA · not yet recruiting
- NCT07196410 — KAN-004 for Immune-Related Diarrhea or Colitis · Phase 1 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06131580 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Centre hospitalier de l'Université de Montréal (CHUM)
- Last refreshed: 14 November 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06131580.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing