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DRACULA1 Partum Depression: an Integrated Molecular-pharmaco-imaging Study")
Post-partum depression (PPD) is a prevalent subtype of major depressive disorder that causes a significant distress to the woman and substantial impact on the whole family. Many studies implicate the glutamatergic system in pathological processes relevant to PPD disorders. There is evidence that cell adhesion molecules (CAMs) play a key role in how glutamatergic circuits wire up during development and how glutamatergic synapses, once formed, operate. However, it is unclear how dysregulation in diverse CAMs alter glutamatergic circuitries responsible for emotional and social behavior. Here, the investigators propose to evaluate the molecular and neurobiological underpinnings of PPD focusing on CAMs at glutamatergic synapses by using an integrated approach from mouse models to human patients. Moreover, the investigators will also perform a pilot study to investigate the impact of selective antidepressants, known to be linked to CAMs, in both human and mice.
Details
| Lead sponsor | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico |
|---|---|
| Status | NOT_YET_RECRUITING |
| Enrolment | 15 |
| Start date | Mon Jan 01 2024 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Thu Apr 30 2026 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Post-partum Depression
Interventions
- Citalopram
Countries
Italy