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NCT06129214
Partial Synovectomy in Articular Side of Quadriceps Tendon Verified to Reduce Crepitus in Retrospective Study
NA trial testing Prepectoral in Osteoarthritis, Knee in 78 participants. Currently enrolling.
6 October 2025
Quick facts
| Lead sponsor | Gangnam Severance Hospital |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 78 |
| Start date | 16 October 2023 |
| Primary completion | 6 October 2025 |
| Estimated completion | 6 October 2025 |
| Sites | 1 location across South Korea |
Drugs / interventions tested
- Prepectoral
- Subpectoral
Conditions studied
- Osteoarthritis, Knee — all drugs for Osteoarthritis, Knee →
- Rheumatoid Arthritis, Knee — all drugs for Rheumatoid Arthritis, Knee →
- Spontaneous Osteonecrosis of Knee — all drugs for Spontaneous Osteonecrosis of Knee →
Sponsor
Gangnam Severance Hospital
Who can join
19 and older, any sex, with Osteoarthritis, Knee or Rheumatoid Arthritis, Knee. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Crepitus causing unsatisfied result to patients after posterior stabilized total knee arthroplasty. Recent retrospective study demonstrated removal of hyperplastic synovium in distal quadriceps caused reduce of crepitus. However, this study has limitation of time gap exist between arms, different in observation time and bias caused by retrospective review. Thus aim of this study is that by randomized trial, verified hyperplastic synovium in distal quadriceps causing crepitus. Target enrolled patients in this study are scheduled to perform both total knee arthroplasty. Experimental group is randomized side (right or left) of knee, and control group is other side of knee. Both arms decided by randomized number table. Crepitus measured after 3mo, 6mo, 1year after surgical treatment
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06129214
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Gangnam Severance Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06129214 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Gangnam Severance Hospital
- Last refreshed: 21 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06129214.
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