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NCT06128798
Effect of Preoperative Immunonutrition Versus Standard Oral Nutrition in Patient Undergoing Colorectal Surgery.
NA trial testing Oral Impact in Colorectal Neoplasms in 58 participants. Status unknown.
25 September 2024
Quick facts
| Lead sponsor | Hospital Universiti Sains Malaysia |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | basic science |
| Enrollment | 58 |
| Start date | 26 September 2023 |
| Primary completion | 25 September 2024 |
| Estimated completion | 25 September 2024 |
| Sites | 1 location across Malaysia |
Drugs / interventions tested
- Oral Impact
- Nutren Optimum
Conditions studied
- Colorectal Neoplasms — all drugs for Colorectal Neoplasms →
Sponsor
Hospital Universiti Sains Malaysia
Who can join
18 and older, any sex, with Colorectal Neoplasms. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a randomised controlled clinical trial . The investigators aim to compare the effects of preoperative immune modulating enteral nutrition and standard oral nutrition supplement on clinical outcomes of the patients undergo colorectal cancer surgery. The main questions it aims to answer are: 1. Does immunonutrition preoperatively facilitate earlier return of Gastrointestinal function? 2. Does immunonutrition significantly reduce risk of post-operative surgical site infections? 3. Does immunonutrition significantly reduce duration of hospital stay in patients undergoing colorectal surgery? Immunonutrition can be defined as modulation of either the activity of the immune system, or modulation of the consequences of activation of the immune system, by nutrients or specific food items fed in amounts above those normally encountered in the diet. Oral IMPACT is readily available immunonutrition consist of 3.3 g of arginine,0.8 g of omega-3 fatty acids and 3.0 g of nucleotides per servings. Nutren Optimum is a balanced nutritional supplement that enhance body natural defence and support recovery during illness. However, it does not consist all the component of immunonutritons. Hence , Oral IMPACT will be used as study sample on experimental arm whereas Nutren optimum will be used as study sample on control arm. Partipicant will be randomised into this two arm and then they will consume the respective arm study material for total of 7 days preoperatively. Data will be collected in post operative period and will be analysed.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effects of preoperative immunonutrition <i>vs</i> standard oral nutrition in patients undergoing colorectal surgery: A randomized controlled trial.
Pannirselvam M, Zakaria Z, Wong MP, Abdul Satar MHS, et al · · 2025 · PMID 41024777 · DOI 10.4240/wjgs.v17.i9.108127
Verify or expand the search:
- PubMed search for NCT06128798
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06128798 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospital Universiti Sains Malaysia
- Last refreshed: 13 November 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06128798.
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