NCT06125743 is a NA clinical trial of Usual Care in Lymphedema of the Head and Neck, sponsored by Abramson Cancer Center at Penn Medicine.

Who is sponsoring NCT06125743?

NCT06125743 is sponsored by Abramson Cancer Center at Penn Medicine.

What drugs are being tested in NCT06125743?

Interventions in NCT06125743: Usual Care, In-Person LEF-SMP, Telehealth LEF-SMP.

What condition does NCT06125743 study?

NCT06125743 studies Lymphedema of the Head and Neck.

Is NCT06125743 still recruiting?

NCT06125743 is currently recruiting now. Last updated 14 August 2025.

Last reviewed 2025-08-14 · How we verify

NCT06125743

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Self-Management for Head and Neck Lymphedema and Fibrosis [PROMISE Trial]

Recruiting now NA Last updated 14 August 2025

What this trial tests

NA trial testing Usual Care in Lymphedema of the Head and Neck in 204 participants. Currently enrolling.

Timeline

29 March 2024

Primary endpoint
31 August 2026

31 August 2026

Quick facts

Lead sponsor	Abramson Cancer Center at Penn Medicine
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	supportive care
Enrollment	204
Start date	29 March 2024
Primary completion	31 August 2026
Estimated completion	31 August 2026
Sites	2 locations across United States

Drugs / interventions tested

Usual Care
In-Person LEF-SMP
Telehealth LEF-SMP

Conditions studied

Lymphedema of the Head and Neck — all drugs for Lymphedema of the Head and Neck →

Sponsor

Abramson Cancer Center at Penn Medicine — full company profile →

Who can join

18 and older, any sex, with Lymphedema of the Head and Neck. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this study is to evaluate the effectiveness of a standardized lymphedema and fibrosis self-management program (LEF-SMP) to improve LEF self-management and reduce LEF-associated symptom burden, functional deficits, and improve quality of life in head and neck cancer (HNC) survivors.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Study protocol for a multi-site randomized clinical trial of an intervention program to promote self-management among head and neck cancer survivors with lymphedema and fibrosis [PROMISE trial].
Deng J, Abene J, Huang L, Murphy BA. · · 2025 · PMID 41084063 · DOI 10.1186/s13063-025-09089-x

Verify or expand the search:

Other trials of Usual Care

Trials testing the same drug.

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Other recruiting trials for Lymphedema of the Head and Neck

Currently open trials in the same condition.

NCT06837480 — Photobiomodulation in Head and Neck Cancer-Related Chronic Lymphedema · NA · recruiting

Other Abramson Cancer Center at Penn Medicine trials

Trials by the same sponsor.

NCT07478848 — Radiation, Oral Vancomycin, and CAR-T for B-Cell Lymphomas · Phase 1 · not yet recruiting
NCT07059611 — Neoadjuvant Intra-tumoral RP2 and FLOT in Gastroesophageal Adenocarcinoma · Phase 2 · not yet recruiting
NCT07454499 — Engaging M-health for Symptom Monitoring and Health Promotion for Women on Endocrine Therapy for Breast Cancer (EmSHAPE) · NA · not yet recruiting
NCT07222241 — Comparing Numbing Techniques in Mohs Micrographic Surgery · NA · recruiting
NCT06837480 — Photobiomodulation in Head and Neck Cancer-Related Chronic Lymphedema · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06125743 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Abramson Cancer Center at Penn Medicine
Last refreshed: 14 August 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06125743.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing