NCT06119477 is a NA clinical trial of Bioceramic Putty Apical Plugs in Immature Teeth, sponsored by Damascus University.

Who is sponsoring NCT06119477?

NCT06119477 is sponsored by Damascus University.

What condition does NCT06119477 study?

NCT06119477 studies Immature Teeth, Periapical Lesion.

Is NCT06119477 still recruiting?

NCT06119477 is currently completed. Last updated 24 August 2025.

Last reviewed 2025-08-24 · How we verify

NCT06119477

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Three Techniques in Bioceramic Apexification for Necrotic Immature Incisors

Completed NA Last updated 24 August 2025

What this trial tests

NA trial testing Bioceramic Putty Apical Plugs in Immature Teeth in 45 participants. Completed in 20 May 2025.

Timeline

5 May 2023

Primary endpoint
22 August 2024

20 May 2025

Quick facts

Lead sponsor	Damascus University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	45
Start date	5 May 2023
Primary completion	22 August 2024
Estimated completion	20 May 2025
Sites	1 location across Syria

Drugs / interventions tested

Bioceramic Putty Apical Plugs
Single Cone Gutta-percha with Bioceramic Sealer
Combination of Bioceramic Putty and Sealer

Conditions studied

Immature Teeth — all drugs for Immature Teeth →
Periapical Lesion — all drugs for Periapical Lesion →

Sponsor

Damascus University

Who can join

Adults 7 to 11, any sex, with Immature Teeth or Periapical Lesion. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this randomized clinical trial is to find the most effective Bioceramic-based apexification procedures in children with immature necrotic maxillary incisors. The main questions they aims to answer are: * What is the best Bioceramic apexification technique regarding the post-operative pain and the periapical healing ? * What is the best Bioceramic apexification technique regarding the bioceramics extrusion and the required time ? Participants will under gone Bioceramic apexification procedures which root canal preparing, disinfecting, filling, and restoring. Then, the patient will asked to come to follow-up appointments for clinical and radiological evaluations If there is a comparison group: Researchers will compare Bioceramic Putty Apical Plugs, Single Cone Gutta-percha with Bioceramic Sealer, and Combination of Bioceramic putty and sealer technique to find the best effective technique.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Root Development Following Bioceramic Material Application in Immature Permanent Teeth: A Case Series With 24-Month Follow-Up.
Alsayed Tolibah Y, Bshara N, Abbara MT, Alhaji M, et al · · 2025 · cited 1× · PMID 41169957 · DOI 10.1155/crid/1530438
Randomized Trial of Bioceramic Apical Barrier Methods in Necrotic Immature Incisors: Effects on Pain, Extrusion, and Procedure Duration.
Alsayed Tolibah Y, Bshara N, Aljabban O, Abbara MT, et al · · 2025 · cited 1× · PMID 41153605 · DOI 10.3390/children12101423

Verify or expand the search:

Other Damascus University trials

Trials by the same sponsor.

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NCT07426523 — Effectiveness of Needle-Free Infiltration Anesthesia in Reduction of Dental Pain and Anxiety During Local Anesthesia. · NA · completed
NCT07366788 — Clinical Outcomes of Mandibular Primary Molar Extraction Using Physics Forceps in Children · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06119477 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Damascus University
Last refreshed: 24 August 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06119477.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing