Last reviewed · How we verify

NCT06116903: ExoGLIE

Clinical Relevance of Detecting Molecular Abnormalities in Glial Tumor Exosomes

Recruiting now NA Last updated 13 December 2024
What this trial tests

NA trial testing Blood sampling in Glioma in 60 participants. Currently enrolling.

Timeline
11 April 2024
Primary endpoint
15 May 2025
15 December 2025

Quick facts

Lead sponsorUniversity Hospital, Limoges
PhaseNA
StatusRecruiting now
Study typeINTERVENTIONAL
Allocationna
Designsingle group
Maskingnone
Primary purposediagnostic
Enrollment60
Start date11 April 2024
Primary completion15 May 2025
Estimated completion15 December 2025
Sites1 location across France

Drugs / interventions tested

Conditions studied

Sponsor

University Hospital, Limoges

Who can join

18 and older, any sex, with Glioma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this pilot study is that exosomes constitute a more interesting support for analyzes allowing a broader screening of molecular alterations to be carried out with more reliable, more sensitive and more efficient results than the reference Foundation One Liquid CDx test.

Publications & conference data

7 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Insight into the Functional Dynamics and Challenges of Exosomes in Pharmaceutical Innovation and Precision Medicine.
    Sharma A, Yadav A, Nandy A, Ghatak S. · · 2024 · cited 40× · PMID 38931833 · DOI 10.3390/pharmaceutics16060709
  2. Engineered and Mimicked Extracellular Nanovesicles for Therapeutic Delivery.
    Poinsot V, Pizzinat N, Ong-Meang V. · · 2024 · cited 16× · PMID 38607173 · DOI 10.3390/nano14070639
  3. Exosomes and solid cancer therapy: where are we now?
    Zemanek T, Danisovic L, Nicodemou A. · · 2025 · cited 15× · PMID 39961904 · DOI 10.1007/s12032-025-02626-3
  4. Immunomodulatory effects and clinical application of exosomes derived from mesenchymal stem cells.
    Yi YF, Fan ZQ, Liu C, Ding YT, et al · · 2025 · cited 9× · PMID 40160689 · DOI 10.4252/wjsc.v17.i3.103560
  5. Harnessing the potential of small extracellular vesicle biomarkers for cancer diagnosis and prognosis with advanced analytical technologies.
    Tam CWL, Yam JWP. · · 2025 · cited 5× · PMID 40896292 · DOI 10.1515/jtim-2025-0019
  6. The role of exosomes in brain tumors: Mechanisms, diagnosis, and therapeutic prospects.
    Falih Shamikh Al-Saedi H, Khalid Younis Al-Bahadli W, Murih Hatab W, Abdolmaleki A. · · 2026 · PMID 42079023 · DOI 10.22038/ijbms.2025.88573.19183
  7. Exosomes in glioma: mechanistic insights on biological, therapeutic, and diagnostic perspective.
    Tandon R, Kumar S, Handa M, Srivastava N. · · 2025 · PMID 39957239 · DOI 10.1080/20415990.2025.2466410

Verify or expand the search:

Other trials of Blood sampling

Trials testing the same drug.

Other recruiting trials for Glioma

Currently open trials in the same condition.

Other University Hospital, Limoges trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06116903.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing