Last reviewed · How we verify
NCT06116903: ExoGLIE
Clinical Relevance of Detecting Molecular Abnormalities in Glial Tumor Exosomes
NA trial testing Blood sampling in Glioma in 60 participants. Currently enrolling.
15 May 2025
Quick facts
| Lead sponsor | University Hospital, Limoges |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 60 |
| Start date | 11 April 2024 |
| Primary completion | 15 May 2025 |
| Estimated completion | 15 December 2025 |
| Sites | 1 location across France |
Drugs / interventions tested
- Blood sampling — full drug profile →
Conditions studied
- Glioma — all drugs for Glioma →
Sponsor
University Hospital, Limoges
Who can join
18 and older, any sex, with Glioma. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this pilot study is that exosomes constitute a more interesting support for analyzes allowing a broader screening of molecular alterations to be carried out with more reliable, more sensitive and more efficient results than the reference Foundation One Liquid CDx test.
Publications & conference data
7 peer-reviewed publications reference this trial (live from Europe PMC):
-
Insight into the Functional Dynamics and Challenges of Exosomes in Pharmaceutical Innovation and Precision Medicine.
Sharma A, Yadav A, Nandy A, Ghatak S. · · 2024 · cited 40× · PMID 38931833 · DOI 10.3390/pharmaceutics16060709 -
Engineered and Mimicked Extracellular Nanovesicles for Therapeutic Delivery.
Poinsot V, Pizzinat N, Ong-Meang V. · · 2024 · cited 16× · PMID 38607173 · DOI 10.3390/nano14070639 -
Exosomes and solid cancer therapy: where are we now?
Zemanek T, Danisovic L, Nicodemou A. · · 2025 · cited 15× · PMID 39961904 · DOI 10.1007/s12032-025-02626-3 -
Immunomodulatory effects and clinical application of exosomes derived from mesenchymal stem cells.
Yi YF, Fan ZQ, Liu C, Ding YT, et al · · 2025 · cited 9× · PMID 40160689 · DOI 10.4252/wjsc.v17.i3.103560 -
Harnessing the potential of small extracellular vesicle biomarkers for cancer diagnosis and prognosis with advanced analytical technologies.
Tam CWL, Yam JWP. · · 2025 · cited 5× · PMID 40896292 · DOI 10.1515/jtim-2025-0019 -
The role of exosomes in brain tumors: Mechanisms, diagnosis, and therapeutic prospects.
Falih Shamikh Al-Saedi H, Khalid Younis Al-Bahadli W, Murih Hatab W, Abdolmaleki A. · · 2026 · PMID 42079023 · DOI 10.22038/ijbms.2025.88573.19183 -
Exosomes in glioma: mechanistic insights on biological, therapeutic, and diagnostic perspective.
Tandon R, Kumar S, Handa M, Srivastava N. · · 2025 · PMID 39957239 · DOI 10.1080/20415990.2025.2466410
Verify or expand the search:
- PubMed search for NCT06116903
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Currently open trials in the same condition.
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Other University Hospital, Limoges trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06116903 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Limoges
- Last refreshed: 13 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06116903.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing