NCT06116162

Comparison of SVF-gel Filling and CO2 Fractional Laser on Atrophic Acne Scar Treatment

Completed NA Last updated 3 November 2023

What this trial tests

NA trial testing SVF-gel Filling and CO2 fractional laser in Autologous Fat Graft Harvesting, SVF-gel Preparation and Filling in 18 participants. Completed in 20 January 2023.

Timeline

20 January 2021

Primary endpoint
20 July 2022

20 January 2023

Quick facts

Lead sponsor	Xijing Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	single group
Masking	single
Primary purpose	treatment
Enrollment	18
Start date	20 January 2021
Primary completion	20 July 2022
Estimated completion	20 January 2023
Sites	2 locations across China

Drugs / interventions tested

• SVF-gel Filling and CO2 fractional laser

Conditions studied

• Autologous Fat Graft Harvesting, SVF-gel Preparation and Filling — all drugs for Autologous Fat Graft Harvesting, SVF-gel Preparation and Filling →
• CO2 Fractional Laser Treatment by Using Acupulse Device — all drugs for CO2 Fractional Laser Treatment by Using Acupulse Device →

Sponsor

Xijing Hospital

Who can join

Adults 16 to 35, any sex, with Autologous Fat Graft Harvesting, SVF-gel Preparation and Filling or CO2 Fractional Laser Treatment by Using Acupulse Device. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background Adipose extracellular matrix/stromal vascular fraction gel（SVF-gel）, which contains adipose-derived stem cells, endothelial cells, smooth muscle cells, pericytes, and other cell components.

Objective To determine the efficacy and safety of SVF-gel for treating acne scars and to compare the results with CO2 fractional laser.

Methods Seventeen patients with moderate to severe acne scars were treated with SVF-gel filling and CO2 fractional laser through a 24-week, randomized split-face study. One randomly assigned half side of each patient's received one SVF-gel filling treatment and the other side by two CO2 fractional laser treatment once one months. Clinical improvement was assessed by two blinded investigators with Echelle d'Evaluation Clinique des Cicatrices d'acne (ECCA) scale, VISIA and Antaro-3D detection.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Comparison of the Effects of Adipose Extracellular Matrix/Stromal Vascular Fraction Gel Injection and CO<sub>2</sub> Fractional Laser on Atrophic Acne Scar in Asians Through a 24-Week Prospective, Randomized, Split-Face Study.
   Zhao T, Li M, Wang J, Liu J, et al · · 2025 · cited 1× · PMID 40112029 · DOI 10.1111/jocd.70131