Last reviewed · How we verify
NCT06114212: TRANS-CANN
Deep Repetitive Transcranial Magnetic Stimulation for Cannabis Use Disorder
NA trial testing dTMS stimulation via the H4 coil in Cannabis Use Disorder in 12 participants. Completed in 17 April 2025.
17 April 2025
Quick facts
| Lead sponsor | St. Joseph's Healthcare Hamilton |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | other |
| Enrollment | 12 |
| Start date | 26 March 2024 |
| Primary completion | 17 April 2025 |
| Estimated completion | 17 April 2025 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- dTMS stimulation via the H4 coil
Conditions studied
- Cannabis Use Disorder — all drugs for Cannabis Use Disorder →
Sponsor
St. Joseph's Healthcare Hamilton — full company profile →
Who can join
Adults 25 to 65, any sex, with Cannabis Use Disorder. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
There is a credible basis for lateral prefrontal cortex and insula deep repetitive transcranial magnetic stimulation (dTMS) stimulation as a treatment for cannabis use disorder (CUD), but no studies to date have examined this. Evidence of benefit could expand the treatment options available for CUD but require randomized controlled trials (RCTs) to evaluate its efficacy. Toward an RCT of this intervention, the proposed study is a phase 1 open-label pilot trial of dTMS for adults with CUD. This study will establish the viability of an H4 protocol constituting an active arm of a future double-blind RCT.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Phase 1 Open-Label Pilot Trial of H4 Deep Repetitive Transcranial Magnetic Stimulation for Adults With Moderate-to-Severe Cannabis Use Disorder.
MacKillop J, McIntyre-Wood C, Vandehei E, Yaya H, et al · · 2026 · PMID 41733532 · DOI 10.1016/j.neurom.2026.01.003
Verify or expand the search:
- PubMed search for NCT06114212
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Cannabis Use Disorder
Currently open trials in the same condition.
- NCT07523633 — Effect of Semaglutide on Cannabis Use in Adults With Cannabis Use Disorder · Phase 2 · recruiting
- NCT07056894 — Effects of Action-Based Cognitive Remediation on Substance Misuse in Early Phase Psychosis · NA · recruiting
- NCT07218471 — Cannabis Reduction and Functional Outcomes · NA · recruiting
- NCT07184983 — RS-tDCS for Cannabis Use Disorder: The C.A.R.E.S. Initiative · NA · recruiting
- NCT06883162 — Cannabis-Tobacco Co-Use Treatment Study · Phase 3 · recruiting
Other St. Joseph's Healthcare Hamilton trials
Trials by the same sponsor.
- NCT06638125 — 3-Dimensional Virtual Reality Modelling With Intravascular Indocyanine Green Fluorescence Mapping for Targeted Pulmonary · Phase 1, PHASE2 · not yet recruiting
- NCT07495228 — Cognitive Processing Therapy for Childbirth-Related Post-Traumatic Stress Disorder · NA · not yet recruiting
- NCT07387965 — A Brief Cannabis Use Psychoeducation Intervention for Eating Disorder Patients · NA · not yet recruiting
- NCT07349316 — The Effects of Weight and Nutrition Education on Weight Control Beliefs, Body Image, Self-Esteem and Eating Patterns in · NA · not yet recruiting
- NCT07250893 — Resolving Early Life Stress: Psychotherapy Outcomes and Neurobiology in Complex Depression · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06114212 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by St. Joseph's Healthcare Hamilton
- Last refreshed: 30 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06114212.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing