NCT06099483

The Effect of Exercise on Brain Functions

Completed NA Last updated 22 March 2024

What this trial tests

NA trial testing Action observation and motor imagery in Pulmonary in 33 participants. Completed in 30 September 2023.

Timeline

1 August 2023

Primary endpoint
30 September 2023

30 September 2023

Quick facts

Lead sponsor	Istanbul Medipol University Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	basic science
Enrollment	33
Start date	1 August 2023
Primary completion	30 September 2023
Estimated completion	30 September 2023
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

• Action observation and motor imagery
• Active breathing exercise
• Control group — full drug profile →

Conditions studied

• Pulmonary — all drugs for Pulmonary →
• EEG — all drugs for EEG →

Sponsor

Istanbul Medipol University Hospital

Who can join

Adults 18 to 55, any sex, with Pulmonary or EEG. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Concept of action simulation; It is an internal representation of motor programs that does not involve explicit movement. Motor imagery method (MI) or movement observation (HG) method are considered two separate action simulation methods that activate motor regions in the brain. Both methods remain a popular and effective tool for improving motor learning. Research has shown that clinicians working in rehabilitation settings are aware of the needs of patients, athletes, etc. are recommended as methods that participants can use to improve their motor skills.

Motor imagery training is a dynamic mental process in which a movement is mentally visualized without any visible movement or any voluntary motor muscle activation. Movement observation training is a method that involves internal, real-time motor simulation of movements in which the observer visually perceives movements performed by another. Mirror neurons, located primarily in the rostral part of the inferior parietal lobe and the ventral premotor cortex, are activated both when an action is physically performed and when the action is observed being performed by another person. Studies using neuroimaging techniques have provided support for this theory by showing that many areas known to be active during action simulation, such as the dorsal pre-motor cortex, supplementary motor area, superior parietal lobe, and intraparietal sulcus, are indeed active during both HG and MI. There is evidence in the literature that MI and HG also trigger sympathetic nervous system activation. There may be changes in respiration, heart rate and skin temperature, as well as an increase in electrodermal activity.

EEG is an inexpensive, noninvasive, and simple examination that can be used to evaluate neurophysiological functions by measuring electrical activity. Understanding the mechanism of beta rhythms is important because they are associated with conscious thinking, logical thinking, memory and problem solving, whereas suppression of beta waves contributes to depression and cognitive decline.

This study will investigate the effectiveness of exercising or watching or imagining exercise on brain functions.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. The Acute Effects of Motor Imagery Combined With Action Observation Breathing Exercise on Cardiorespiratory Responses, Brain Activity, and Cognition: A Randomized, Controlled Trial.
   Atak E, Ataç A. · · 2025 · PMID 40026414 · DOI 10.1155/cdr/6460951