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NCT06088706
Evaluation of the Effect of Different Doses of Ozone Therapy on Pain and Function of Patients With Knee Osteoarthritis
NA trial testing Intra-articular injection of ozone in Osteo Arthritis Knee in 60 participants. Completed in 1 May 2024.
10 April 2024
Quick facts
| Lead sponsor | Ahmad Nazari |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 20 November 2023 |
| Primary completion | 10 April 2024 |
| Estimated completion | 1 May 2024 |
| Sites | 1 location across Iran |
Drugs / interventions tested
- Intra-articular injection of ozone
Conditions studied
- Osteo Arthritis Knee — all drugs for Osteo Arthritis Knee →
Sponsor
Ahmad Nazari
Who can join
Adults 50 to 75, any sex, with Osteo Arthritis Knee. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study is designed as a randomized clinical trial that will be conducted in Hazrat Rasool Akram Hospital in Tehran. Patients with knee osteoarthritis were selected based on the study entry criteria and written consent was obtained from them. Then, by random assignment, patients will be divided into three treatment groups: control group (under oxygen gas injection), intervention group 1 (intra-articular injection of ozone with a dose of 20 micrograms) and intervention group 2 (intra-articular injection of ozone with a dose of 40 micrograms).
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Ozone therapy for knee osteoarthritis: a literature visualization analysis of research hotspots and prospects.
Liu Q, Liu J, Cao G, Liu Y, et al · · 2025 · cited 5× · PMID 39648327 · DOI 10.4103/mgr.medgasres-d-24-00099 -
Efficacy of two doses of intra-articular ozone therapy for pain and functional mobility in knee osteoarthritis: a double-blind randomized trial.
Arjmanddoust Z, Nazari A, Moezy A. · · 2025 · cited 3× · PMID 40050950 · DOI 10.1186/s42358-025-00443-w
Verify or expand the search:
- PubMed search for NCT06088706
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Osteo Arthritis Knee
Currently open trials in the same condition.
- NCT07258693 — Multimodal Treatment of Knee Osteoarthritis: Therapeutic Exercise and Noninvasive Neuromodulation (NESA) Versus Therapeu · NA · active not recruiting
- NCT07141316 — Effects of Blood Flow Restriction Combined With Electrostimulation After Knee Arthroplasty · NA · active not recruiting
- NCT06485843 — An Study to Evaluate Safety and Tolerability of OA-SYS in Subjects With Moderate to Severe Osteoarthritis of the Knee Jo · Phase 2 · recruiting
- NCT06965946 — Intermittent Hypoxia-Hyperoxia Combined With Physical Therapy for Knee Osteoarthritis · NA · recruiting
- NCT06058169 — Effects of Home Base Whole-body Vibration in Osteoarthritis. (VIBE-Rx2) · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06088706 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ahmad Nazari
- Last refreshed: 16 July 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06088706.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing