NCT06072833

Characterizing and Addressing Financial Toxicity in AYAs With Cancer

Completed NA Results posted Last updated 16 March 2026

What this trial tests

NA trial testing Patient Financial Education / Navigation in Cancer in Adolescence in 26 participants. Completed in 28 February 2025.

Timeline

15 November 2023

Primary endpoint
28 February 2025

28 February 2025

Quick facts

Lead sponsor	Columbia University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	health services research
Enrollment	26
Start date	15 November 2023
Primary completion	28 February 2025
Estimated completion	28 February 2025
Sites	1 location across United States

Drugs / interventions tested

• Patient Financial Education / Navigation

Conditions studied

• Cancer in Adolescence — all drugs for Cancer in Adolescence →

Sponsor

Columbia University

Who can join

Adults 15 to 39, any sex, with Cancer in Adolescence. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Number of Participants Who Completed the Intervention Primary · Up to 6 months

This is to assess the feasibility of intervention completion. Intervention completion is defined as participants who have demonstrated contact with community partners at any time before the end of 6 months.

Group	Value	95% CI
Participants Eligible (Screened Positive)	21

Number of Eligible Participants Who Received the Intervention Primary · Up to 6 months

This is to measure interest and the need for help by community partners that can provide patient financial education and navigation.

Group	Value	95% CI
Patients Eligible (Screened Positive)	23

Comprehensive Score of Financial Toxicity (COST Measure) Score Secondary · Baseline, 6 months

The COST is a patient-reported outcome measure that describes the financial distress experienced by cancer patients. It is a 11-item questionnaire with a score range of 0-44. Lower COST values indicate higher toxicity. Higher scores indicate lower financial toxicity .

Baseline

Group	Value	95% CI
Participants Eligible (Screed Positive)	10.47	± 4.78

6 months

Group	Value	95% CI
Participants Eligible (Screed Positive)	16.53	± 8.58

Sponsor's own description

The overall aims of this study are to address two important gaps in care for AYA cancer patients: 1) a financial toxicity measurement tool to assess AYA-specific needs, and 2) an intervention for mitigating financial toxicity in this population. Aim 1 involves adapting the COSTA measure and assessing the psychometric properties of the measure for a racial/ethnically diverse group of AYAs. Aim 2 and 3 involve the development and pilot testing of our novel financial education/ navigation (FE/FN) intervention.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. Pilot feasibility of a financial and health-related social needs navigation intervention (AYA-NAV) for adolescents and young adults with Cancer: Study protocol for a prospective, single-arm study.
   Khurana RK, Valera K, Raghunathan R, Gallagher KD, et al · · 2025 · cited 1× · PMID 40726516 · DOI 10.1016/j.conctc.2025.101523
2. Development of Educational Guidance Sessions for Adolescents and Young Adults With Cancer and Their Caregivers: A Component of the AYA-NAV Intervention.
   DiCola K, Khurana RK, Alvarado S, Moya G, et al · · 2026 · PMID 42217181 · DOI 10.1177/10732748261453116
3. AYA-NAV, A Patient-Informed, Tailored Needs Navigation Intervention for Adolescents and Young Adults With Cancer: A Pilot Study.
   Khurana RK, Raghunathan R, Alvarado S, Crespo S, et al · · 2025 · PMID 41449703 · DOI 10.1177/10732748251409888