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NCT06070233: SPASM
Radiosurgery Treatment for Spasticity Associated With Stroke, SCI & Cerebral Palsy
NA trial testing stereotactic radiosurgery (SRS) dorsal root rhizotomy radiomodulation in Spasticity as Sequela of Stroke in 22 participants. Currently enrolling.
31 December 2026
Quick facts
| Lead sponsor | Ohio State University |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 22 |
| Start date | 12 October 2023 |
| Primary completion | 31 December 2026 |
| Estimated completion | 31 December 2026 |
| Sites | 2 locations across United States |
Drugs / interventions tested
- stereotactic radiosurgery (SRS) dorsal root rhizotomy radiomodulation
- Sham
Conditions studied
- Spasticity as Sequela of Stroke — all drugs for Spasticity as Sequela of Stroke →
- Spastic Cerebral Palsy — all drugs for Spastic Cerebral Palsy →
- Spasticity, Muscle — all drugs for Spasticity, Muscle →
Sponsor
Ohio State University
Who can join
16 and older, any sex, with Spasticity as Sequela of Stroke or Spastic Cerebral Palsy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A scientific study is being done to test a special treatment for people who have spasticity or tight muscles. This treatment is called "stereotactic radiosurgery dorsal rhizotomy." It uses very accurate beams of radiation to target certain nerves in the back to help loosen up the muscles. In this study, people are put into two groups by chance: one group gets the real treatment, and the other group gets a "fake" treatment that doesn't do anything. This fake treatment is called a "sham." Doing this helps make sure the study is fair and the results are true. After the people in the study get their treatment, the researchers will watch and see how they do. They will check if their muscles are less stiff and if they have any side effects. By looking at the results from both groups, the researchers can find out if the special treatment really helps people with spasticity. Patients who got the "fake" treatment will be eligible to receive the "real" treatment after 6 months.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Radiosurgical Irradiation of Spinal Nerve Roots for the Management of Spasticity: A Systematic Review.
Izhar M, Hori YS, Kattaa AH, Park DJ, et al · · 2026 · PMID 41911102 · DOI 10.1159/000551781
Verify or expand the search:
- PubMed search for NCT06070233
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Spasticity as Sequela of Stroke
Currently open trials in the same condition.
- NCT06055725 — A Study to Estimate How Often Post-stroke Spasticity Occurs and to Provide a Standard Guideline on the Best Way to Monit · active not recruiting
- NCT06017960 — Effects of Dry Needling on Electromyographic Activity and Ultrasonographic Characteristics in Post-Stroke Spasticity · NA · recruiting
- NCT05179473 — Prognosis and Diagnosis of Spasticity in Acute-post Stroke Patients · recruiting
Other Ohio State University trials
Trials by the same sponsor.
- NCT06542458 — Under-Represented Communities Diagnosed With SCD or MCI Through Tele-Cog · not yet recruiting
- NCT07217548 — Solving Stigma Through POV Simulation: Enhancing Pharmacist Empathy-based Practices With Sickle Cell Disease Patients · NA · enrolling by invitation
- NCT07215221 — Implementation of TBI-RECOVER in Substance Use Treatment · NA · not yet recruiting
- NCT07278427 — Reducing Parental Substance Use and Enhancing Family Resilience Among Rural Families Through Ohio START · recruiting
- NCT07490444 — Metric-Optimized Spectacle Prescriptions for Children With Down Syndrome · Phase 2 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06070233 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ohio State University
- Last refreshed: 19 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06070233.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing