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NCT06055881: BOSS
Primary Breast Oligoprogressive Sites Treated With Radiotherapy to Obviate the Need to Change Systemic Therapy
NA trial testing Biospecimen Collection in Breast Carcinoma in 45 participants. Currently enrolling.
1 May 2027
Quick facts
| Lead sponsor | Mayo Clinic |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 45 |
| Start date | 23 October 2023 |
| Primary completion | 1 May 2027 |
| Estimated completion | 1 May 2032 |
| Sites | 2 locations across United States |
Drugs / interventions tested
- Biospecimen Collection — full drug profile →
- Surveys
- Stereotactic Body Radiation Therapy (SBRT) — full drug profile →
- Computed Tomography
- Magnetic Resonance Imaging
- Positron Emission Tomography
Conditions studied
- Breast Carcinoma — all drugs for Breast Carcinoma →
- Anatomic Stage IV Breast Cancer AJCC v8 — all drugs for Anatomic Stage IV Breast Cancer AJCC v8 →
- Metastatic Breast Cancer — all drugs for Metastatic Breast Cancer →
Sponsor
Mayo Clinic
Who can join
18 and older, female only, with Breast Carcinoma or Anatomic Stage IV Breast Cancer AJCC v8. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study assesses if metastasis-directed radiation therapy (Stereotactic body radiation therapy - SBRT) can delay a change in systemic therapy, and if circulating tumor cells in the bloodstream can help guide treatment options in metastatic breast cancer patients with progressive disease
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Local treatment for oligoprogressive metastatic sites of breast cancer: efficacy, toxicities and future perspectives.
Merloni F, Palleschi M, Gianni C, Sirico M, et al · · 2024 · cited 3× · PMID 39312051 · DOI 10.1007/s10585-024-10312-3
Verify or expand the search:
- PubMed search for NCT06055881
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Currently open trials in the same condition.
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Other Mayo Clinic trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06055881 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mayo Clinic
- Last refreshed: 6 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06055881.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing