Last reviewed · How we verify
NCT06053229
Effect of Percussive Massage on Skeletal Muscle During Limb Immobilization
NA trial testing percussive massage in Massage Therapy in 36 participants. Currently enrolling.
31 December 2024
Quick facts
| Lead sponsor | Brigham Young University |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 36 |
| Start date | 1 March 2023 |
| Primary completion | 31 December 2024 |
| Estimated completion | 31 July 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- percussive massage
- Leg Immobilization
Conditions studied
- Massage Therapy — all drugs for Massage Therapy →
- Muscular Atrophy — all drugs for Muscular Atrophy →
Sponsor
Brigham Young University
Who can join
Adults 18 to 50, any sex, with Massage Therapy or Muscular Atrophy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The primary aims of this study are to determine the effect of percussive massage (30 min/session, 2 sessions/day, daily) during 10 days of unilateral limb immobilization on preserving muscle, vascular, and mitochondrial function. The following hypotheses will be tested: Hypothesis 1: Percussive massage will attenuate the loss of size, strength and endurance over the immobilization period compared to the control group, as measured by MRI, maximal isometric and isokinetic force production and muscle endurance test using Biodex dynamometry. Hypothesis 2: Percussive massage will attenuate the loss of vascular function and blood flow compared to the control group as measured by passive leg movement and femoral artery blood flow. Hypothesis 3: Percussive massage will attenuate the loss of skeletal muscle mitochondrial function and decrease H2O2 production during immobilization compared to the control group, as measured by high-resolution respirometry.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy.
Ahmadi M, Seaman C, Marchant ED, Bartling J, et al · · 2026 · PMID 42013026 · DOI 10.1152/function.109.2025
Verify or expand the search:
- PubMed search for NCT06053229
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06053229 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Brigham Young University
- Last refreshed: 13 August 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06053229.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing