Who is sponsoring NCT06051487?

NCT06051487 is sponsored by Mansoura University.

What drugs are being tested in NCT06051487?

Interventions in NCT06051487: titanium dioxide nanoparticles in test group.

What condition does NCT06051487 study?

NCT06051487 studies Gingival Inflammation.

Is NCT06051487 still recruiting?

NCT06051487 is currently completed. Last updated 28 September 2023.

Last reviewed 2023-09-28 · How we verify

NCT06051487

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Evaluation of Anti Bacterial Effect of Titanium Dioxide Nanoparticles on Baseplates of Twin Block

Completed NA Last updated 28 September 2023

What this trial tests

NA trial testing titanium dioxide nanoparticles in test group in Gingival Inflammation in 26 participants. Completed in 25 April 2023.

Timeline

11 March 2022

Primary endpoint
11 October 2022

25 April 2023

Quick facts

Lead sponsor	Mansoura University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	prevention
Enrollment	26
Start date	11 March 2022
Primary completion	11 October 2022
Estimated completion	25 April 2023
Sites	1 location across Egypt

Drugs / interventions tested

titanium dioxide nanoparticles in test group

Conditions studied

Gingival Inflammation — all drugs for Gingival Inflammation →

Sponsor

Mansoura University

Who can join

Adults 9 to 14, any sex, with Gingival Inflammation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background The objective of this study was to evaluate the antibacterial effect of Titanium dioxide nanoparticles incorporated into the acrylic baseplates of maxillary part of twin block appliances in orthodontic patients during the treatment period. Material and methods Twenty-six patients were selected randomly and divided into two groups(n=13). Test group patients were used orthodontic functional appliances containing Titanium dioxide nanoparticles in acrylic baseplates. Control group patients were used orthodontic functional appliances without Titanium dioxide nanoparticles in acrylic baseplates. Swap samples were taken from palatal gingiva facing fitting surface of acrylic component of maxillary part of twin block appliance for each patient at five times intervals (base line sample, after one, two, four, and six months) then cultured in blood agar plates to calculate bacterial colony count.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Evaluation of the antibacterial effect of titanium dioxide nanoparticles combined with acrylic laminates for functional orthodontic appliances: a randomized controlled clinical trial.
Elabd GM, Eldars W, Shamaa MS, Tawfik MA. · · 2024 · cited 8× · PMID 38178135 · DOI 10.1186/s12903-023-03805-2
Nanoscale Approaches to Oro-Dental Tissue Engineering: A Review of Strategies, Composites, and Translational Challenges.
Wang P, Ye Y, Mei K, Chen B, et al · · 2026 · PMID 41878129 · DOI 10.2147/ijn.s575296
Current trends and research advances on the application of TiO2 nanoparticles in dentistry: How far are we from clinical translation?
Mohammadi H, Moradpoor H, Beddu S, Mozaffari H, et al · · 2025

Verify or expand the search:

Other recruiting trials for Gingival Inflammation

Currently open trials in the same condition.

NCT07104019 — Biofiller and Gingival Phenotype Thickening · NA · recruiting
NCT07100574 — Bacteria in Dental Plaque and Atheroma Plaque · recruiting
NCT06752291 — EFFECTIVENESS of WATER FLOSS in PLAQUE REMOVAL and PREVENTION of WHITE SPOT LESIONS in ORTHODONTIC PATIENTS: a RANDOMISE · NA · active not recruiting

Other Mansoura University trials

Trials by the same sponsor.

NCT05785377 — Neostigmine as an Adjuvant in Tranversus Abdominis Plane (TAP) Block in Cesarean Section Under Spinal Anesthesia · NA · not yet recruiting
NCT07509567 — Conventional Palatal Crib Versus Bonded Spurs for Anterior Open Bite Treatment · NA · not yet recruiting
NCT07393178 — Efficacy & Safety of High Power vs. Low Power Holmium Laser in Mini-PCNL for Large Renal Stones · NA · not yet recruiting
NCT07436182 — Mitochondrial Redox Modulation in Newly Diagnosed Type 2 Diabetes: A Randomized Controlled Trial Comparing Imeglimin vs. · Phase 4 · not yet recruiting
NCT07534943 — Effectiveness of Oleanolic Acid as Intracanal Medicament on Infectious/Inflammatory Contents in Teeth With Apical Period · NA · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06051487 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Mansoura University
Last refreshed: 28 September 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06051487.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing