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NCT06043024
Characteristics of Cytokine Response in Patients With Temporomandibular Disorders Treated With Occlusal Splint Therapy
NA trial testing Stabilization occlusal splint in Temporomandibular Joint Disorders in 36 participants. Completed in 16 August 2024.
16 August 2024
Quick facts
| Lead sponsor | Josip Juraj Strossmayer University of Osijek |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 36 |
| Start date | 16 August 2023 |
| Primary completion | 16 August 2024 |
| Estimated completion | 16 August 2024 |
| Sites | 1 location across Croatia |
Drugs / interventions tested
- Stabilization occlusal splint
Conditions studied
- Temporomandibular Joint Disorders — all drugs for Temporomandibular Joint Disorders →
Sponsor
Josip Juraj Strossmayer University of Osijek
Who can join
Adults 18 to 65, any sex, with Temporomandibular Joint Disorders. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this intervention study is to determine the effect of occlusal splint (OS) therapy on the concentration of inflammatory cytokines in serum and gingival crevicular fluid (GCF) in patients with temporomandibular disorders (TMDs). Aims are: * to determine cytokines level in GCF and serum before and after OS therapy * to determine the degree of psychosocial dysfunction and oral health-related quality of life before and after OS therapy * investigate the correlation between cytokines level in GCF and serum * to determine the effect of OS on treatment outcomes, pain intensity, dysfunction, and psychosocial status of patients with painful TMD. Participants will be asked to complete self-assessment questionnaires, and GCF and blood samples will be collected before beginning of the OS therapy and at follow-up examinations one month and two months after.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Stabilization Splint Therapy for Patients with Temporomandibular Disorders Improves Opening Movements and Jaw Limitation and Attenuates Pain by Influencing the Levels of IL-7, IL-8, and IL-13 in the Gingival Crevicular Fluid.
Sikora R, Duspara K, Matić A, Petrović A, et al · · 2025 · cited 1× · PMID 40142185 · DOI 10.3390/medicina61030375
Verify or expand the search:
- PubMed search for NCT06043024
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Temporomandibular Joint Disorders
Currently open trials in the same condition.
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- NCT06721104 — Balance, TMJ, Social Adaptive Assessment in Individuals With Autism Spectrum Disorder · recruiting
- NCT06500390 — Temporomandibular Disorder in Use of Levonorgestrel Intrauterine System · NA · recruiting
- NCT06813040 — Efficacy of Repetitive Transcranial Magnetic Stimulation in Temporomandibular Disorders. · NA · recruiting
Other Josip Juraj Strossmayer University of Osijek trials
Trials by the same sponsor.
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- NCT06545812 — Immune Response During the Conservative and Minimal Invasive Treatment of Pain Caused by Lumbar Disc Herniation · NA · completed
- NCT06316284 — miRNA in Chronic Kidney Diseases · not yet recruiting
- NCT06316271 — Endothelial Function in Prehypertension · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06043024 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Josip Juraj Strossmayer University of Osijek
- Last refreshed: 19 September 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06043024.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing